Evidence map›Paper›PMID 41947544›Full record

ArticleHuman brain mapping2026

Spatial Entropy of Brain Network Landscapes: A Novel Method to Assess Spatial Disorder in Brain Networks.

Clayton C McIntyre, Shannon M O'Donnell, Mohammadreza Khodaei, Robert G Lyday, Jonathan H Burdette, Paul J Laurienti

Abstract read
In one paragraph

Article in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Clayton C McIntyreWake Forest Graduate School of Arts and Sciences, Neuroscience Graduate Program, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0003-2397-9453
Shannon M O'DonnellWake Forest Graduate School of Arts and Sciences, Neuroscience Graduate Program, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0009-0009-2440-8055
Mohammadreza KhodaeiSchool of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Winston-Salem, North Carolina, USA.
Robert G LydayDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jonathan H BurdetteDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Paul J LaurientiDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Funding

Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BRIAN A MCCOOL · 2018 to 2026
$16.2M
CRCNS: Functional Brain Networks with Tensioned Stability for Optimal ProcessingR01AA029926 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOLLT, ERIK, LAURIENTI, PAUL · 2021 to 2024
$1.3M
The bidirectional relationship between brain network dynamics and adolescent alcohol useF31AA032409 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Clayton McIntyre · 2025 to 2026
$100k
NIAAA NIH HHS F31 AA032409NIAAA NIH HHS F31AA032409NIAAA NIH HHS P50 AA026117NIAAA NIH HHS P50AA026117NIAAA NIH HHS R01 AA029926NIAAA NIH HHS R01AA029926
6 · The paper itself

Abstract

In this work, we introduce a method for mapping the spatial entropy of functional brain network community structure images in brain space. Entropy maps indicate the extent to which the network communities present in a local area are ordered or disordered. We demonstrate how spatial entropy can be quantified for each voxel in the brain according to the network community affiliations of surrounding voxels. This process results in interpretable maps of brain network entropy. We show that local entropy decreases in predictable brain regions during working memory and music-listening tasks. We suggest that these regional entropy reductions reflect self-organization of neural processes in support of functionally localized cognitive tasks. In summary, we propose a method that allows group-level comparison of the brain network community structure identified in individuals. Analyses in this work provide a framework for future analyses of spatial entropy in complex networks that can be mapped to Euclidean space-both within the brain and in other contexts.

Indexed as

Auditory PerceptionBrainBrain MappingConnectomeImage Processing, Computer-AssistedMagnetic Resonance ImagingMemory, Short-TermNerve NetEntropyHumansMusicbrain networksentropymusicself‐organizationworking memory

Identifiers

PMID41947544
PMCPMC13058231

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.