Evidence map›Paper›PMID 41947520›Full record

ArticleJournal of fish diseases2026

Investigating the Antiviral Mechanism of Kaempferol Against Grouper Iridovirus: Combined Evaluation of In Vitro Activity and In Vivo Efficacy.

Nijia Xue, Lin Huang, Jieying Yu, Jia Cai, Zhengzhao Liu, Yibing Wang, Shu Cheng, Junxiang Lai, Ying Pan, Qing Yu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fish diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nijia XueKey Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning, P.R. China.
Lin HuangGuangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Nanning, P.R. China.
Jieying YuGuangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Nanning, P.R. China.
Jia CaiGuangdong Engineering Technology Research Center of Indigenous Valuable Fish Reproductive Regulation and Breeding, Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Fisheries College, Guangdong Ocean University, Zhanjiang, P.R. China.
Zhengzhao LiuGuangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Nanning, P.R. China.
Yibing WangSchool of Marine Sciences and Biotechnology, Guangxi Minzu University, Nanning, P.R. China.
Shu ChengGuangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Nanning, P.R. China.
Junxiang LaiGuangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Nanning, P.R. China.ORCID https://orcid.org/0000-0002-7139-1454
Ying PanKey Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning, P.R. China.
Qing YuGuangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Nanning, P.R. China.
Wenhong LiKey Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning, P.R. China.
Pengfei LiKey Laboratory of Aquatic Healthy Breeding and Nutrition Regulation of Guangxi Universities, College of Animal Science and Technology, Guangxi University, Nanning, P.R. China.

Funding

Guangxi Innovation Team Project of National Modern Agricultural Industrial Technology System nycytxgxcxtd-2021-08-02Guangxi Science and Technology Program GUIKEFA[2024]102-2Laibin Science and Technology Program Laikechan 241519National Natural Science Foundation of China 32373175Natural Science Foundation of Guangxi Zhuang Autonomous Region 2022JJA130074Natural Science Foundation of Guangxi Zhuang Autonomous Region 2024GXNSFFA010017Postgraduate Education Innovation Project of Guangdong Ocean University 202422
6 · The paper itself

Abstract

Singapore grouper iridovirus (SGIV) is one of the major pathogens that pose significant threats to the aquaculture industry. Kaempferol is a flavonoid compound extracted from Illicium verum Hook.f. (star anise), a material that is both edible and used in traditional medicine. In this study, we evaluated the antiviral effects of kaempferol against SGIV in vitro and in vivo, and elucidated the antiviral mechanism. Our study found that kaempferol could effectively resist SGIV infection in vitro and in vivo. Kaempferol might destroy the SGIV envelope and interfere with the attachment, invasion, and replication stages of SGIV infection. Transcriptomic analysis showed that differentially expressed genes regulated by kaempferol were enriched in ribosome, NF-κB, and phospholipase D signalling pathways. Further screening of immunity-related genes and pathway analysis revealed that antiviral immune responses were mainly governed by the JAK-STAT, PI3K-Akt, and TNF signalling pathways. This study demonstrated that kaempferol exhibited significant antiviral effects against SGIV through multiple mechanisms and had the potential to become an anti-SGIV fishery drug. These findings provide a theoretical basis for the development of effective drugs for the prevention and treatment of SGIV.

Indexed as

Antiviral AgentsBassDNA Virus InfectionsFish DiseasesIridovirusKaempferolsRanavirusAnimalsGene Expression ProfilingAntiviral AgentskaempferolKaempferolsAntiviral mechanismsKaempferolSingapore grouper iridovirus

Identifiers

PMID41947520
PMCPMC13432017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.