ArticleCardio-oncology (London, England)2026
Temporal trends, cardiovascular complications, and outcomes in patients receiving CAR T-cell therapy: a 6-year nationwide analysis.
Article in Cardio-oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of relapsed or refractory hematologic malignancies. However, real-world data describing cardiovascular complications with CAR T-cell therapy remain limited.
methodsUsing the National Inpatient Sample, we identified hospitalizations involving CAR T-cell therapy from 2017 to 2022. Temporal trends, in-hospital mortality, cardiovascular complications, and other clinical outcomes were evaluated using survey-weighted regression models.
resultsAmong 13,370 weighted hospitalizations, CAR T-cell use increased from 70 cases in 2017 to 4,335 in 2022. The overall in-hospital mortality rate was 3.4%. Cardiovascular complications were observed in a subset of patients, including arrhythmias in 20.2%, acute myocardial infarction in 0.5%, stroke in 1.0%, cardiogenic shock in 0.2%, and major adverse cardiovascular and cerebrovascular events in 4.5%. Atrial fibrillation was the most common arrhythmia (11.1%), followed by conduction abnormalities (3.9%). The prevalence of arrhythmias increased with advancing age, reaching 48.3% in patients older than 80 years. Acute kidney injury occurred in 14.4%, with 1.7% requiring renal replacement therapy. Cytokine release syndrome occurred in 61.0% in 2021 and 62.1% in 2022, while immune effector cell–associated neurotoxicity syndrome was observed in 24.2% in 2022. Mean length of stay was 18.3 days, and inflation-adjusted hospitalization costs increased from $83,939 in 2017 to $378,507 in 2022.
conclusionsCAR T-cell therapy utilization increased substantially in the United States over the study period, with relatively low in-hospital mortality but notable cardiovascular complications, particularly arrhythmias. These findings highlight the importance of cardiovascular risk assessment and monitoring in patients undergoing CAR T-cell therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.