ArticleBMC nutrition2026
Adherence, safety, bioavailability, and acceptability of amaranth grain flatbread during pregnancy: evidence from a cluster randomized trial in Sidama region, Ethiopia.
Article in BMC nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06536153 (Maternal Under-nutrition and Effect of Amaranth Grain Flat-bread on Anemia in Northern Zone of Sidama Region, Ethiopia.), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Under-nutrition and Effect of Amaranth Grain Flat-bread on Anemia in Northern Zone of Sidama Region, Ethiopia.
Who cites it
1 citing paper in PubMed.
- Amaranth Seeds as Lactic Acid Bacteria Fermentation Substrates: Prospects for Metabiotic Foods and Functional Ingredients.Foods (Basel, Switzerland) · 2026Review
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMaternal anemia is a major public health concern in Ethiopia. Nutrient-dense local foods like amaranth may improve iron status during pregnancy. This study evaluated adherence, safety, bioavailability, and acceptability of amaranth grain flatbread during pregnancy in Sidama region, Ethiopia.
methodsBetween September 2024 and February 2025, a two-arm parallel cluster randomized controlled trial was carried out in the Hawela Lida district, Ethiopia. A total of 306 pregnant women (< 12 weeks gestation) were randomized to amaranth (n = 153) and maize flatbread (n = 153) for six months. Primary outcomes: haemoglobin concentration and iron deficiency anemia (IDA). Secondary outcomes: adherence, safety, bioavailability biomarkers, and acceptability. Blood samples were analyzed using HemoCue and ELISA. Mixed-effects models accounted for clustering and baseline covariates.
resultsOf 306 participants, 293 (95.8%) completed the study. The amaranth group had higher mean haemoglobin concentration (adjusted β = + 2.67, 95% CI: 2.41–2.91) and lower IDA (ARR = 0.47, 95% CI: 0.26–0.84) than controls. Adherence was higher in amaranth arm (AOR = 1.25, 95% CI: 1.08–1.44) and no serious adverse events occurred. Acceptability was greater in the intervention arm (AOR = 1.72, 95% CI: 1.21–2.46). Qualitative results supported quantitative findings, with participants reporting enthusiasm and readiness to continue consuming.
conclusionDaily amaranth flatbread is safe, highly acceptable, and improves maternal iron status, supporting its integration into maternal nutrition programs in low-resource settings.
trial registrationClinicalTrials.gov, NCT06536153, registered on July 30, 2024.
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