Evidence map›Paper›PMID 41947139›Full record

ArticleBMC oral health2026

Water-soluble yeast β-glucan accelerates oral ulcer healing in rats via collagen synthesis and epithelial regeneration.

Yeting Tu, Hua Huang, Mengyun Zhang, Xiaomin Yu, Zixue Lei, Zhong Zhang, Xingyan Tan, Xiaorui Zhang, Chongyun Bao, Yang Yao and 1 more

Abstract read
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In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yeting Tu *State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Hua Huang *State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Mengyun ZhangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Xiaomin YuDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
Zixue LeiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Zhong ZhangState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Xingyan TanWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Xiaorui ZhangWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Chongyun BaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China.
Yang YaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China. yaoyang9999@126.com.
Yuqing LiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, 610041, China. liyuqing@scu.edu.cn.

Funding

Deep Earth Probe and Mineral Resources Exploration - National Science and Technology Major Project 2024ZD1000600, 2024ZD1000604Fundamental Research Funds for the Central Universities, Research and Develop Program, West China Hospital of Stomatology Sichuan University RD-03-202402Sichuan Provincial Science and Technology Support Program 2025ZNSFSC0770Technological Innovation and Development Project of Chengdu Bureau of Science and Technology 2024-YF05-00571-SN
6 · The paper itself

Abstract

backgroundOral ulcer is a common, painful lesion that heals slowly and easily becomes secondary-infected. β-glucan, a well-known immunomodulator, has shown potential in promoting wound repair. However, the therapeutic efficacy of its water-soluble form on oral mucosal wounds remains insufficiently studied. Therefore, this study aimed to evaluate the effects of water-soluble yeast β-glucan on the healing of oral ulcers in a rat model.

methodsForty rats were randomly assigned to five groups (n = 8): (1) negative control (2), standard care control (0.12% chlorhexidine), and (3–5) experimental groups treated with 0.1%, 0.5%, or 1.0% water-soluble yeast β-glucan, respectively. Oral ulcers were chemically induced, and lesion size and clinical status were monitored daily. Histopathological changes were assessed by hematoxylin–eosin, Masson trichrome, and immunohistochemical staining. Data were analyzed by one-way analysis of variance using GraphPad Prism 10.0; P < 0.05 was considered statistically significant.

resultsOn day 6, water-soluble yeast β-glucan- and chlorhexidine-treated rats exhibited significantly smaller ulcer areas, faster healing rates, complete epithelialization, and improved histological scores compared with the negative controls (P < 0.05). Water-soluble yeast β-glucan treatment also increased collagen deposition (P < 0.05). Moreover, water-soluble yeast β-glucan-treated animals showed significantly greater weight gain than the negative controls (P < 0.0001).

conclusionsThis study establishes the beneficial effect of water-soluble yeast β-glucan on oral mucosal repair and provides a clear rationale for its clinical evaluation in human oral ulcers.

Indexed as

beta-GlucansCollagenOral UlcerRegenerationWound HealingAnimalsChlorhexidineDisease Models, AnimalMaleMouth MucosaRandom AllocationRatsRats, Sprague-DawleyWaterbeta-GlucansChlorhexidineCollagenWaterImmunomodulationOral ulcerWater-solubleWound healingYeast β-glucan

Identifiers

PMID41947139
PMCPMC13217810

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.