Evidence map›Paper›PMID 41947132›Full record

SynthesisMalaria journal2026

Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review.

Jarinne Camilo Landim Nasserala, Francisco Naildo Cardoso Leitão, Amanda Vitória Rodrigues Dos Santos, Alice Maria Costa Martins, Gdayllon Cavalcante Meneses, Rayane Nascimento de Souza, Geraldo Bezerra da Silva Junior, Elizabeth De Francesco Daher, Mauro José de Deus Morais

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Malaria journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jarinne Camilo Landim NasseralaPostgraduate Program in Public Health (PPG/SC), Universidade Federal do Acre, Rodovia BR 364, Km 04, Distrito Industrial, Rio Branco, AC, CEP 69920-900, Brazil. jarinne.nasserala@ufac.br.
Francisco Naildo Cardoso LeitãoPostgraduate Program in Health Sciences in Western Amazon (PPG/CSAO), Universidade Federal do Acre (UFAC), Rio Branco, AC, Brazil.
Amanda Vitória Rodrigues Dos SantosUniversidade Federal do Acre (UFAC), Rio Branco, AC, Brazil.
Alice Maria Costa MartinsFaculty of Pharmacy, Dentistry and Nursing, Laboratory of Nephrology and Tropical Diseases, Universidade Federal do Ceara, Fortaleza, Ceará, Brazil.
Gdayllon Cavalcante MenesesFaculty of Pharmacy, Dentistry and Nursing, Laboratory of Nephrology and Tropical Diseases, Universidade Federal do Ceara, Fortaleza, Ceará, Brazil.
Rayane Nascimento de SouzaFaculty of Pharmacy, Dentistry and Nursing, Laboratory of Nephrology and Tropical Diseases, Universidade Federal do Ceara, Fortaleza, Ceará, Brazil.
Geraldo Bezerra da Silva JuniorMedical Course, Postgraduate Programs in Medical Sciences and Public Health, Universidade de Fortaleza, Fortaleza, Ceará, Brazil.
Elizabeth De Francesco DaherFaculty of Medicine, Department of Clinical Medicine, Universidade Federal do Ceara, Postgraduate Program in Medical Sciences, Fortaleza, Ceará, Brazil.
Mauro José de Deus MoraisResearcher at the Multidisciplinary Laboratory of Scientific Studies and Writing in Health Sciences, Universidade Federal do Acre, Rio Branco, AC, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria-associated acute kidney injury (AKI) is a severe complication strongly associated with increased mortality. Early identification of high-risk patients remains difficult, as serum creatinine is a late marker of renal dysfunction. Renal and endothelial injury biomarkers may improve early detection and prognostic stratification.

methodsA systematic review was conducted according to PRISMA 2020 guidelines and prospectively registered in PROSPERO (CRD42025642952). A systematic search was performed in PubMed, Scopus, and Web of Science. The search strategy combined the terms ("kidney" AND "biomarkers" AND "malaria"). Included studies were evaluated using the Newcastle-Ottawa Scale (NOS) and the Methodological Index for Non-Randomized Studies (MINORS).

resultsThe combined evaluation of renal and endothelial biomarkers, together with clinical and laboratory parameters, allows improved characterization of AKI in malaria and supports risk stratification. Elevated biomarker levels were consistently associated with increased risk of renal complications and adverse outcomes.

conclusionRenal and endothelial biomarkers may represent promising tools for early detection and monitoring of malaria-associated AKI, with potential to improve risk stratification and clinical management.

Indexed as

Acute Kidney InjuryBiomarkersMalariaHumansBiomarkersAcute kidney injuryBiomarkersEndothelial dysfunctionKidneyMalaria

Identifiers

PMID41947132
PMCPMC13188605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.