ArticleBMC pediatrics2026
Impact of different vitamin D supplementation doses on vitamin D status and bone metabolism in preterm infants.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm infants are at high risk for vitamin D deficiency due to limited transplacental transfer and increased postnatal requirements. Optimal vitamin D supplementation dosing in this population remains controversial.
objectiveTo compare the effects of 400 IU/day versus 800 IU/day vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] levels, mineral metabolism, renal outcomes, and neonatal morbidities in preterm infants.
methodsIn this prospective cohort study, 66 preterm infants born at ≤ 34 weeks’ gestation and admitted to the neonatal intensive care unit (NICU) were followed. Infants were categorized into two groups according to the documented daily vitamin D supplementation regimen used in routine clinical practice (400 IU/day or 800 IU/day). Serum 25(OH)D, calcium, phosphorus, and alkaline phosphatase (ALP) levels were measured at admission and at 1 and 2 months postnatally. Renal ultrasonography and urinary calcium-to-creatinine (Ca/Cr) ratios were evaluated at 2 months. Neonatal morbidities, including bronchopulmonary dysplasia (BPD), were recorded.
resultsAt admission, vitamin D deficiency or insufficiency (< 20 ng/mL) was highly prevalent in both groups. By postnatal 1 month, more than 90% of infants achieved vitamin D sufficiency, and all infants were sufficient by 2 months. The increase in serum 25(OH)D from admission to 2 months was significantly greater in the 800 IU/day group (p = 0.040). Calcium, phosphorus, and ALP levels remained within physiological ranges in both groups. No cases of vitamin D toxicity were observed, and renal ultrasonography findings were comparable between groups. In the unadjusted analysis, the incidence of BPD was lower in infants receiving 800 IU/day compared with those receiving 400 IU/day.
conclusionVitamin D supplementation with 800 IU/day appeared metabolically safe in preterm infants and resulted in greater increases in serum 25(OH)D levels compared with 400 IU/day. A lower incidence of BPD was observed in the higher-dose group, although randomized controlled trials are needed to confirm these findings. CLINICAL
trial registrationNot applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.