ArticleCommunications chemistry2026
Heparin microarray-based specific interaction assay of marine sulfated polysaccharides with antithrombin Ⅲ.
Article in Communications chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Marine sulfated polysaccharides (SPs) are promising candidates for new anticoagulant drug development, necessitating efficient method to evaluate their anticoagulant activity at the molecular level. In this work, a heparin microarray-based competitive strategy was developed to investigate the specific interactions between SPs and antithrombin Ⅲ (AT). The strategy is based on the principle that SPs competitively bind to the active domain of AT, reducing the signal of AT binding to immobilized heparin on microarrays. Validation was performed using established anticoagulants heparin and enoxaparin as model analytes. After optimizing key experimental conditions, the method successfully determined the IC
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