ArticleNature microbiology2026
Local peptidoglycan composition defines division site selection in Streptococcus pneumoniae.
Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Accurate division site placement is essential for bacteria to produce viable daughter cells. In the ovoid-shaped Streptococcus pneumoniae, previous work showed that division site placement depends on both the protein MapZ and chromosome segregation, although specific mechanisms remain unclear. Here we imaged fluorescently labelled S. pneumoniae, observing division site placement at the cell equator, the widest part of the cell, not at the mid-cell. Disruption of chromosome segregation neither affected MapZ nor divisome positioning, suggesting that division site selection can occur independently of chromosome segregation. MapZ localization depends on the sequential recruitment of two peptidoglycan decarboxylases, DacA and DacB, to the division site. DacA and DacB activity during early peptidoglycan synthesis generates a distinctive, tetrapeptide signature required for MapZ binding. As the cell cycle progresses, this signature becomes enriched at cell equators, recruiting MapZ so that these equators eventually serve as the division site in daughter cells. These findings update the mechanism of division site placement in S. pneumoniae.
Indexed as
Identifiers
41946898What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.