Evidence map›Paper›PMID 41946895›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Association of dynamic blood pressure trajectory during pregnancy with adverse birth outcomes: a large prospective cohort study in China.

Wubulitalifu Dawuti, Jie Du, Xiaoli Tian, Mengmeng Li, Bing Li, Yali Zhang, Weixian Gao, Zhiwen Li, Tao Huang

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Wubulitalifu DawutiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Jie DuChinese Center for Diseases Control and Prevention, National Institute for Nutrition and Health, Beijing, China.
Xiaoli TianDepartment of Epidemiology and Biostatistics, School of Public Health, Xinjiang medical University, Urumqi, China.
Mengmeng LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Bing LiSchool of Economics and Management, Beijing University of Technology, Beijing, China.
Yali ZhangInstitute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, China.
Weixian GaoInstitute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, China.
Zhiwen LiInstitute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Beijing, China. lizw@bjmu.edu.cn.
Tao HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. huang.tao@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the associations between dynamic blood pressure (BP) trajectories during pregnancy and adverse birth outcomes using data from the China-US Collaborative Project on Neural Tube Defect Prevention. Among 281,224 pregnant women (mean age 25.07 ± 3.57 years), group-based trajectory modeling (GBTM) identified three distinct systolic (SBP) and diastolic (DBP) BP patterns: "Low-stable", "Fast-increasing", and "High-stable". Compared to the Low-stable SBP group, women with Fast-increasing or High-stable SBP trajectories had significantly elevated risks of adverse outcomes, including an 16% higher risk of preterm birth (adjusted OR = 1.16, 95% CI:1.09-1.23) and 37% increased risk of low birth weight (LBW) (aOR=1.37,1.27-1.49) in the High-stable group. For DBP, the Fast-increasing trajectory showed the strongest associations, with a 19% higher preterm birth risk (aOR=1.19,1.11-1.26) and 63% increased LBW risk (aOR=1.63,1.51-1.76). Each 10 mmHg rise in SBP and DBP from mid-to-late pregnancy was independently linked to higher risks of preterm birth (SBP: aOR=1.10,1.06-1.12; DBP: aOR=1.16,1.13-1.20) and low birth weight (SBP: aOR=1.12,1.09-1.14; DBP: aOR=1.22,1.18-1.26). These findings highlight that dynamic BP changes during pregnancy are robust predictors of adverse birth outcomes, underscoring the importance of continuous BP monitoring for early risk identification and intervention.

Indexed as

Blood PressurePregnancy OutcomePremature BirthAdultChinaFemaleHumansInfant, Low Birth WeightInfant, NewbornPregnancyProspective StudiesYoung AdultAdverse birth outcomesCohort studyDigital hypertensionGroup-based trajectory modeling (GBTM)

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PMID41946895

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