Evidence map›Paper›PMID 41946873›Full record

ArticleNature microbiology2026

Spatio-temporal dynamics of Hendra virus in Australia reveal stable maintenance of diverse viral clades among Pteropus bats.

Claude Kwe Yinda, John-Sebastian Eden, Erica T Prates, Anna Vlot, Sarah van Tol, Sarah L Anzick, Jianning Wang, Kim Halpin, Benny Borremans, Tamika J Lunn and 16 more

Abstract read
In one paragraph

Article in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Claude Kwe Yinda *Laboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0002-5195-5478
John-Sebastian Eden *Centre for Virus Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.ORCID http://orcid.org/0000-0003-1374-3551
Erica T Prates *Oak Ridge National Laboratory, Oak Ridge, TN, USA.
Anna VlotOak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0001-9538-987X
Sarah van TolLaboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0002-9905-920X
Sarah L AnzickGenomics Research Section, Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Jianning WangAustralian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Canberra, Australia.
Kim HalpinAustralian Centre for Disease Preparedness, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Canberra, Australia.
Benny BorremansWildlife Health Ecology Research Organization, San Diego, CA, USA.
Tamika J LunnOdum School of Ecology, University of Georgia, Athens, GA, USA.
Kent BarbianGenomics Research Section, Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0001-9861-6150
Brown BullochLaboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0009-0001-6190-0331
Benjamin GreeneLaboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA.
Kimberly Meade-WhiteLaboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA.
Trenton BushmakerLaboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA.ORCID http://orcid.org/0000-0002-2161-4808
Caylee A FalvoDepartment of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Daniel E CrowleyDepartment of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-4262-253X
Devin N Jones-SlobodianDepartment of Ecology, Montana State University, Bozeman, MT, USA.
Manesh ShahBiochemistry and Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN, USA.
Mirko PavicicOak Ridge National Laboratory, Oak Ridge, TN, USA.
William CarrDepartment of Biology, Medgar Evers College, City University of New York, New York, NY, USA.
Craig MartensGenomics Research Section, Research Technologies Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
Daniel JacobsonOak Ridge National Laboratory, Oak Ridge, TN, USA.ORCID http://orcid.org/0000-0002-9822-8251
Raina K PlowrightDepartment of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Alison J PeelSydney Institute for Infectious Diseases, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3538-3550
Vincent J MunsterLaboratory of Virology, Division of Intramural Research, National Institutes of Health, Hamilton, MT, USA. vincent.munster@nih.gov.ORCID http://orcid.org/0000-0002-2288-3196

Funding

NSF | BIO | Division of Environmental Biology (DEB) DEB1716698, EF-2133763/ EF-2231624United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) D18AC00031
6 · The paper itself

Abstract

Hendra virus (HeV) was discovered in 1994 in Australia. Limited genomic data have hindered comprehensive understanding of HeV's evolutionary dynamics. Here we recovered 48 HeV genomes from bats and 9 from horses from Australia between 2016 and 2020, revealing four distinct clades. Each clade was distributed over a large spatial area with multiple clades co-circulating within a single bat roost on the same day and over consecutive years. The diversity and temporal stability of co-circulating clades suggest that viral dynamics are driven by episodic shedding of existing lineages maintained at the population level, rather than immune-driven strain-replacement dynamics. HeV isolates of different clades displayed variation in phenotypic properties but minimal antigenic differences. We provide an overview of evolutionary dynamics, phenotypic properties and assessment of countermeasures for HeV, and provide insights into the processes that maintain virus diversity in bats and influence the potential for viral emergence.

Indexed as

ChiropteraHendra VirusHenipavirus InfectionsAnimalsAustraliaEvolution, MolecularGenetic VariationGenome, ViralHorsesPhylogenySpatio-Temporal Analysis

Identifiers

PMID41946873
PMCPMC13056563

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.