Evidence map›Paper›PMID 41946800›Full record

ArticleNpj imaging2026

Development and validation of an activatable PET radiotracer reporting extracellular myeloperoxidase activity for the detection of unstable atherosclerotic plaque.

George P Keeling, Xiaoying Wang, Weiyu Chen, Nadia Chaher, Ling Gao, Marcelo E Andia, Sergey Tumanov, Piotr Golda, Mohammed M Chowdhury, Prakash Saha and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

George P KeelingSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.
Xiaoying WangSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.
Weiyu ChenHeart Research Institute, Newtown, NSW, Australia.
Nadia ChaherSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.
Ling GaoSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.
Marcelo E AndiaSchool of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Sergey TumanovHeart Research Institute, Newtown, NSW, Australia.
Piotr GoldaLondon Metallomics Facility, King's College London, London, UK.
Mohammed M ChowdhuryDepartment of Vascular Surgery, University of Cambridge, Cambridge, UK.
Prakash SahaSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.
Lefteris LivieratosSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK.
James NadelHeart Research Institute, Newtown, NSW, Australia.
Roland StockerHeart Research Institute, Newtown, NSW, Australia. roland.stocker@hri.org.au.
Alkystis PhinikaridouSchool of Biomedical Engineering and Imaging Sciences, Res. Dept. of Cardiovascular Imaging, King's College London, London, UK. alkystis.1.phinikaridou@kcl.ac.uk.

Funding

British Heart Foundation PG/2019/34897Heart Research Institute Project grant UKIG003King's BHF Centre for Research Excellence grant RE/24/130035
6 · The paper itself

Abstract

Extracellular arterial activity of the pro-inflammatory enzyme myeloperoxidase (MPO) destabilizes atherosclerotic plaque and associates with future atherothrombosis. To facilitate first-in-human studies using extracellular MPO activity as a molecular imaging target to identify high-risk atherosclerotic plaque, we describe [

Identifiers

PMID41946800
PMCPMC13056917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.