Articlenpj aging2026
Aging effects on emotionality, cognition and brain mononuclear cells in Sprague-Dawley rats of both sexes.
Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Aging impairs the function of immune cells and increases susceptibility to diseases such as anxiety and dementia. Nevertheless, some individuals exhibit resilience to age-related impairments, although the mechanisms are still unclear. This study investigated alterations in brain mononuclear cells and their association with age-related behavioral deficits in male and female rats. Flow cytometry was used to analyze the expression of CD45, CX3CR1, and CD163 on brain CD11b+ cells. Aging rats demonstrated reduced anxiety-like behavior, spatial learning, and social play, with certain sex differences. Young adult females showed hyperactivity and higher cognitive flexibility than same-aged males. Aging increased CD45 and CD163 expression within CD11b+ cells. Furthermore, sex-dependent correlations were observed between expression of CD163 and CX3CR1 within CD11b+ cells and locomotor activity in aging. Females might appear to be more susceptible to aging, suggesting microglial activation as a compensatory mechanism. These results suggest immune cell dynamics underlying sex-specific aging behavior.
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Registered trials
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