Evidence map›Paper›PMID 41946712›Full record

ArticleNature communications2026

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.

John Muthii Muriuki, Alexander J Mentzer, Gavin Band, Amanda Y Chong, Alex W Macharia, Reagan M Mogire, Kelvin Mokaya Abuga, Ruth Mitchell, James J Gilchrist, Emily L Webb and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

John Muthii MuriukiKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. jmuriuki@kemri-wellcome.org.ORCID http://orcid.org/0000-0003-4369-9547
Alexander J MentzerCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4502-2209
Gavin BandCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1710-9024
Amanda Y ChongCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4919-2632
Alex W MachariaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0001-5364-9610
Reagan M MogireKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Kelvin Mokaya AbugaKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0002-5726-1776
Ruth MitchellMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-3506-160X
James J GilchristOxford Vaccine Group, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2045-6788
Emily L WebbMRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-4019-7456
Francis M NdunguKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0002-8977-0030
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-7892-193X
Lynette EkunweDepartment of Medicine, University of MS Medical Center, Jackson, USA.ORCID http://orcid.org/0009-0007-6125-5233
Amy R BentleyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0827-9101
Sodiomon B SirimaGroupe de Recherche Action en Sante (GRAS), Ouagadougou, Burkina Faso.ORCID http://orcid.org/0000-0002-0972-4211
Shabir A MadhiSouth African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-7629-0636
Adrian V S HillCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0900-9629
Andrew M PrenticeMRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, The Gambia.ORCID http://orcid.org/0000-0001-5389-451X
Philip BejonKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.ORCID http://orcid.org/0000-0002-2135-7549
Gibran HemaniMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0920-1055
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Manjinder S SandhuDepartment of Epidemiology & Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2725-142X
Alison M ElliottMRC/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.ORCID http://orcid.org/0000-0003-2818-9549
Thomas N WilliamsKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Adebowale AdeyemoNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3105-3231
Sarah H AtkinsonKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. satkinson@kemri-wellcome.org.ORCID http://orcid.org/0000-0002-8360-4402

Funding

Genetic epidemiology of complex diseasesZ01HG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2008 to 2008
$1.7M
Intramural NIH HHS Z01 HG200362NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INIMHD NIH HHS HHSN268201800013IWellcome TrustWellcome Trust 103951Wellcome Trust 106289Wellcome Trust 203077Wellcome Trust 224317Wellcome Trust 226014Wellcome Trust 311117
6 · The paper itself

Abstract

Iron is essential for both humans and pathogens, yet its genetic regulation remains understudied in African populations. Here, we report genome-wide association studies of six iron-related biomarkers in 3928 children from five sites across Africa, with replication in 2868 African American adults and investigate associations with severe malaria and bacteremia. We identify previously unreported loci at genome-wide significance, for transferrin at GTF3C5, and for hepcidin at CHCHD7/SDR16C5. Variants tagging the DUP4 haplotype, encoding the Dantu blood group (rs552439837) are associated with soluble transferrin receptor levels. Variants at GTF3C5 (rs2905094) and DUP4 confer protection against severe malaria and bacteremia. The CHCHD7/SDR16C5 variant (rs73596248) increases hepcidin levels and is associated with reduced risk of Klebsiella pneumoniae and Staphylococcus aureus bacteremia. Polygenic risk scores derived from European data show limited transferability to African populations. In this work, we demonstrate new genetic insights into iron regulation and highlight iron's role in host-pathogen interactions.

Indexed as

BacteremiaGenetic LociIronMalariaAfricaAfrican PeopleChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHepcidinsHumansKlebsiella pneumoniaePolymorphism, Single NucleotideHepcidinsIronTransferrin

Identifiers

PMID41946712
PMCPMC13392482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.