Evidence map›Paper›PMID 41946709›Full record

ArticleNature communications2026

Ponatinib inhibits LCK and PI3K signaling and promotes CD8

Yuki Okuhiro, Sachiko Ito, Keisuke Watanabe, Yue Yan, Kazuhiro Kumagai, Takahiko Sato, Yasuhiro Kojima, Yuki Fujioka, Naoto Takahashi, Hitoshi Kiyoi and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuki OkuhiroDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0009-0004-5253-5370
Sachiko ItoDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0001-9313-7089
Keisuke WatanabeDivision of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center Japan, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6539-2549
Yue YanDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kazuhiro KumagaiDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahiko SatoDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7553-167X
Yasuhiro KojimaLaboratory of Computational Life Science, National Cancer Center, Tokyo, Japan.
Yuki FujiokaDivision of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center Japan, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9449-7462
Naoto TakahashiDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.ORCID http://orcid.org/0000-0002-6758-3787
Hitoshi KiyoiDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0001-6382-9498
Yuka MaedaDivision of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center Japan, Tokyo, Japan.
Takuma KatoDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroyoshi NishikawaDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan. hnishika@ncc.go.jp.ORCID http://orcid.org/0000-0001-6563-9807

Funding

Japan Agency for Medical Research and Development (AMED) 16cm0106301h0001Japan Agency for Medical Research and Development (AMED) 19ae0101074s0401Japan Agency for Medical Research and Development (AMED) 22ama221301h0001Japan Agency for Medical Research and Development (AMED) 22zf0127009h0001Japan Agency for Medical Research and Development (AMED) 24ama221327h0002Japan Agency for Medical Research and Development (AMED) 24ym0126135h0001
6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesImidazolesImmunologic MemoryLymphocyte Specific Protein Tyrosine Kinase p56(lck)Memory T CellsPhosphatidylinositol 3-KinasesPyridazinesAnimalsCell DifferentiationCell Line, TumorFemaleHumansLymphocyte ActivationMiceMice, Inbred C57BLProtein Kinase InhibitorsImidazolesLymphocyte Specific Protein Tyrosine Kinase p56(lck)Phosphatidylinositol 3-KinasesponatinibProtein Kinase InhibitorsPyridazinesReceptors, Chimeric AntigenTyrosine Kinase Inhibitors

Identifiers

PMID41946709
PMCPMC13233839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.