ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026
[Expression of Notch signaling pathway in children with Henoch-Schönlein purpura and its correlation with inflam-matory cytokines].
Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the expression of Notch signaling pathway-related genes in peripheral blood mononuclear cells (PBMCs) of children with Henoch-Schönlein purpura (HSP) and their correlation with inflammatory cytokine levels.
methodsA total of 66 children with initial-onset HSP (30 in the complex HSP group and 36 in the simple HSP group) treated at the Guangzhou Women and Children's Medical Center, along with 28 healthy controls, were enrolled. The messenger RNA (mRNA) expression levels of
resultsCompared with the healthy control group, both the simple and complex HSP groups showed significantly elevated mRNA levels of
conclusionsThe Notch signaling pathway is significantly activated during the acute phase of HSP and may participate in the immunopathological process by regulating the secretion of pro-inflammatory cytokines. The mRNA expression levels of
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