Evidence map›Paper›PMID 41946360›Full record

ArticleCurrent biology : CB2026

The DNA damage response pathway is required for multiciliated cell differentiation.

Cayla E Jewett, Andrew J Holland, Chad G Pearson

Abstract read
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Cayla E JewettDepartment of Molecular Biology and Genetics, Johns Hopkins School of Medicine, North Wolfe Street, Baltimore, MD 21205, USA; Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, East 17(th) Avenue, Aurora, CO 80045, USA. Electronic address: cayla.jewett@cuanschutz.edu.
Andrew J HollandDepartment of Molecular Biology and Genetics, Johns Hopkins School of Medicine, North Wolfe Street, Baltimore, MD 21205, USA; Amgen Research, One Amgen Center Drive, Thousand Oaks, CA 91320, USA. Electronic address: aholla05@amgen.com.
Chad G PearsonDepartment of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, East 17(th) Avenue, Aurora, CO 80045, USA. Electronic address: chad.pearson@cuanschutz.edu.

Funding

Centriole assembly and function for centrosome and cilia biologyR35GM140813 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI CHAD G PEARSON · 2021 to 2026
$3.5M
Centrosome biogenesis and copy number controlR01GM114119 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORMACK, BRENDAN · 2015 to 2023
$3.3M
The role of TRIM37 in driving tumorigenesis and cancer-specific vulnerability to PLK4 inhibitionR01CA266199 · NCI · JOHNS HOPKINS UNIVERSITY · PI Sergi Regot · 2022 to 2026
$2.7M
Molecular mechanism that suppresses the proliferation of cells with supernumerary centriolesR01GM133897 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CORMACK, BRENDAN · 2019 to 2022
$1.9M
NCI NIH HHS R01 CA266199NIGMS NIH HHS R01 GM114119NIGMS NIH HHS R01 GM133897NIGMS NIH HHS R35 GM140813
6 · The paper itself

Abstract

Multiciliated cells (MCCs) lining the airways, reproductive tracts, and brain ventricles construct hundreds of motile cilia, each anchored by a centriole.

Indexed as

Cell DifferentiationCentriolesCiliaDNA DamageDNA RepairAnimalsCell CycleDNA Breaks, Double-StrandedATMcell cyclecentriole amplificationciliaDNA damageDNA-PKH2AXR-loop

Identifiers

PMID41946360
PMCPMC13058275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.