ArticleThe American journal of tropical medicine and hygiene2026
Sickle Trait Hemoglobin Does Not Influence Anopheles Biting Rates.
Article in The American journal of tropical medicine and hygiene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Children with sickle cell trait (HbAS) are protected against severe and symptomatic Plasmodium falciparum (P. falciparum) malaria. Although several within-host resistance mechanisms have been investigated, it is unknown whether this protection is attributable in part to reduced exposure to P. falciparum parasites via mosquito bites. In a 15-month cohort in Western Kenya, mosquito blood meals were matched to human hosts on the basis of short tandem repeat genotypes to determine individual mosquito biting rates. Using a multilevel multivariable model, mosquito biting behavior was assessed with respect to human β-globin genotypes, and no significant difference in biting rate was observed between individuals with wild-type (HbAA) and HbAS genotypes (biting rate ratio: 1.23; 95% CI: 0.86-1.77). These findings suggest that protection against malaria conferred by the sickle cell trait is unlikely to be attributable to reduced exposure to infectious mosquito bites.
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