ArticleBreast (Edinburgh, Scotland)2026
Global patterns and risk factors of breast cancer in women under 35: a population-based study.
Article in Breast (Edinburgh, Scotland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccurate estimates of the global burden of young breast cancer are lacking. This study assesses its global burden and trends to inform control strategies.
methodsUsing Global Burden of Disease (GBD) data (1990-2021) to assess YBC under 35 years in terms of age-standardized incidence rate (ASIR), prevalence rate (ASPR), mortality rate (ASMR), and DALY rate (ASDR). The study accounted for geographic variations and Socio-demographic index (SDI) quintiles, assessing trends and projecting rates to 2050 while examining risk factors. Primary outcomes were age-standardized rates and average annual percent change (AAPC).
resultsIn 2021, YBC accounted for substantial global disease burden, with 81,856 new cases (95% UI: 76,458-87,253), 687,819 prevalent cases (95% UI: 642,400-733,238), 18,597 deaths (95% UI: 17,191-20,003), and 1,178,721 DALYs (95% UI: 1,090,902-1,266,541). From 1990 to 2021, global ASIR (AAPC: 1.3%) and ASMR (AAPC: 0.3%) increased significantly, with projections indicating continued growth through 2050. While ASIR rose across all SDI quintiles, ASMR increased only in low and low-middle SDI quintiles (AAPC: 1.3% and 1.1%), but decreased in high and high-middle SDI quintiles (AAPC: 1.5% and -1.0%). Except for the lowest SDI quintile, YBC proportion within overall breast cancer burden decreased across other SDI quintiles. Dietary risks were the primary driver of YBC mortality, while high BMI showed an inverse association with mortality.
conclusionYBC represents a growing global burden with significant disparities across SDI quintiles. Targeted interventions to address modifiable risk factors and improve healthcare access in less developed regions are essential to mitigate its impact.
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