Evidence map›Paper›PMID 41945989›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2026

Development of physiologically based liver distribution model that incorporates intracellular lipid partitioning and binding to fatty acid binding protein 1.

Yue Winnie Wen, Nina Isoherranen

Abstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Yue Winnie WenDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington.
Nina IsoherranenDepartment of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington. Electronic address: ni2@uw.edu.

Funding

Understanding Fetal Exposure to Cannabinoids Through In Vitro and In Vivo StudiesP01DA032507 · NIDA · UNIVERSITY OF WASHINGTON · PI UNADKAT, JASHVANT D · 2013 to 2023
$12.4M
Mechanisms of Regulation of Retinoic Acid HomeostasisR01DK143511 · NIDDK · UNIVERSITY OF WASHINGTON · PI Nina Isoherranen · 2025 to 2026
$1.2M
NIDA NIH HHS P01 DA032507NIDDK NIH HHS R01 DK143511
6 · The paper itself

Abstract

Steady-state volume of distribution can be predicted using tissue-to-plasma partition coefficients (K

Indexed as

Fatty Acid-Binding ProteinsLipid MetabolismLiverModels, BiologicalAnimalsHumansMaleProtein BindingRatsTissue DistributionFABP1 protein, humanFatty Acid-Binding ProteinsDrug distributionFatty acid binding protein 1Intracellular protein and drug bindingLC-MS/MS proteomics protein quantificationPhysiologically based pharmacokinetic modeling

Identifiers

PMID41945989
PMCPMC13169308

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.