Evidence map›Paper›PMID 41945883›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Multimodal Multiorgan-on-a-Chip Platform for Probing Liver-Tumor Interactions and Advancing Prodrug Screening.

Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Regenerative biomaterials · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dan WangState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Yisong HuangState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Weijian ZhaoState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Tian ChenState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Siyu BaiState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Denghui GuoState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Mengying WangState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Yaoyao ZhaoState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Liang ZhaoState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Guangsheng GuoState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.
Xiayan WangState Key Laboratory of Materials Low-Carbon Recycling, Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Innovation and Translation, Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China.ORCID 0000-0003-1735-0077

Funding

Beijing Outstanding Young Scientist Program BJJWZYJH01201910005017National Natural Science Foundation of China 22127805National Natural Science Foundation of China 22174007National Natural Science Foundation of China 22476223
6 · The paper itself

Abstract

To advance the development of microphysiological systems with enhanced metabolic fidelity, there is a critical need to recapitulate native three-dimensional multicellular architecture, enabling non-invasive, multi-parameter measurements. Here, we present a multimodal multi-OoC platform designed to investigate liver-tumor interactions and streamline prodrug screening. The platform features a sophisticated microfluidic circuit with pneumatically actuated valves for dynamic perfusion and strategically configured microwell arrays that support the formation and maturation of 3D hepatic constructs. By synergistically incorporating real-time electrochemical sensing with automated solid-phase microextraction coupled to mass spectrometry (SPME-LC-MS) for pharmaceutical kinetic analysis, the platform allows nonintrusive, longitudinal monitoring of prodrug metabolism. We further implemented an impedance-based immunosensor for real-time assessment of drug-induced hepatotoxicity, quantifying secreted albumin across clinically relevant concentrations (1-80 µM). As proof of concept, we evaluated the metabolic activation and subsequent antineoplastic efficacy of two prodrugs, capecitabine and tamoxifen, highlighting the system's ability to elucidate hepatic metabolic activation pathways and resultant antineoplastic efficacy. By unifying 3D tissue models with complementary real-time analytical modalities, this work provides a versatile and transformative approach for in vitro drug evaluation and mechanistic organ-organ interaction studies. L. Z. conceived the study. D. W. performed the experiments, analyzed the data, and wrote the manuscript. L. Zhao. wrote and revised the manuscript. X. W., and G. G. helped on revising the manuscript. D. G., M. W., and Y. Z. helped to perform the mass spectrometry testing of the parent drug and its metabolites. T. C. assisted in completing all the work related to the proteomics section. Y. H. and S. B. assisted in the fabrication and characterization of the chip. L. Z. and X. W. supervised the research project. All authors read and approved the final manuscript.

Indexed as

Antineoplastic AgentsLab-On-A-Chip DevicesLiverLiver NeoplasmsProdrugsAnimalsHumansMicrophysiological SystemsAntineoplastic AgentsProdrugsliver metabolismliver‐tumor interactionmultimodal analysismultiorgan‐on‐a‐chipprodrug

Identifiers

PMID41945883
PMCPMC13285169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.