Evidence map›Paper›PMID 41945871›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Androgen Receptor-Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis.

Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Can LiuHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital/ The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Qiu PengHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital/ The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Xiaoyue ZhangHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital/ The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Zhengshuo LiHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital/ The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Yangge WuCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Yuqing WenCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Run ZhengCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Shuanglong WuCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Chenfei ZhouCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Zhengyu HuCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Lanjun ShuCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Xinyi MaCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Qiuyang LiCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Ya MaCancer Research Institute, Xiangya School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Chunlin OuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ming ZhaoNingbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang, China.
Songqing FanDepartment of Pathology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lingyu WeiShanxi Provincial Center For Upper Gastrointestinal Cancer Research and Clinical Translation, Laboratory of Clinical Research Center, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China.
Jian MaHunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital/ The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.ORCID https://orcid.org/0000-0001-9395-0416

Funding

China 111 Project 111-2-12China Postdoctoral Science Foundation 2024M753677China Postdoctoral Science Foundation 2025M771479Fundamental Research Programs of Shanxi Province 202503021211235Graduate Research and Innovation Projects of Hunan Province CX20240025Graduate Research and Innovation Projects of Hunan Province CX20250140Hunan Natural Sciences Foundation 2026JJ30148National Natural Science Foundation of China 82101907National Natural Science Foundation of China 82203233National Natural Science Foundation of China 82373062National Natural Science Foundation of China 82472701Ningbo Municipal Key Medical Discipline (Western Medicine) Development Project 2026-A40Ningbo Top Medical and Health Research Program 2023010211Science and technology innovation plan of Shanxi Higher Education Institutions-Young Academic Leaders 2024Q033
6 · The paper itself

Abstract

Lactoferrin (LF), an innate immunity molecule, showed a strikingly high expression level in the human prostate compared to other tissues and organs, indicating a significant role in prostate physiology. Despite the tumor-suppressive role of lactoferrin established in other malignancies, we reveal its paradoxical oncogenic function in prostate cancer through an androgen receptor (AR)-LF-ferroptosis axis. Utilizing Lf

Indexed as

CarcinogenesisFerroptosisLactoferrinProstatic NeoplasmsReceptors, AndrogenAnimalsDisease Models, AnimalHumansIronMaleMiceMice, KnockoutIronLactoferrinReceptors, Androgenandrogen receptorferroptosislactoferrinprostate cancerTRAMP mouse model

Identifiers

PMID41945871
PMCPMC13334613

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.