Evidence map›Paper›PMID 41945610›Full record

ArticlePLoS neglected tropical diseases2026

Genomic characterisation of Crimean-Congo haemorrhagic fever virus (CCHFV) in Tajikistan identifies a novel reassortant virus.

Jake D'Addiego, Farida Tishkova, Manija Mullojonova, Viktoriya Dzhuraeva, Grant Lythe, Stuart Dent, Carmen Molina-París, Thomas Leitner, Roger Hewson

Abstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jake D'AddiegoDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID https://orcid.org/0000-0003-2249-2942
Farida TishkovaVirology Laboratory, Tajik Research Institute of Preventative Medicine, Dushanbe, Tajikistan.
Manija MullojonovaVirology Laboratory, Tajik Research Institute of Preventative Medicine, Dushanbe, Tajikistan.
Viktoriya DzhuraevaVirology Laboratory, Tajik Research Institute of Preventative Medicine, Dushanbe, Tajikistan.
Grant LytheDepartment of Applied Mathematics, University of Leeds, Leeds, United Kingdom.
Stuart DentPublic Health Microbiology Directorate, UK Health Security Agency, Salisbury, United Kingdom.
Carmen Molina-ParísDepartment of Applied Mathematics, University of Leeds, Leeds, United Kingdom.
Thomas LeitnerTheoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.
Roger HewsonDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Funding

Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
NIAID NIH HHS R01 AI087520
6 · The paper itself

Abstract

Crimean-Congo haemorrhagic fever virus (CCHFV) is an important human tick-borne pathogen, able to cause severe haemorrhagic fever. CCHFV is endemic in Tajikistan, which records between 5-38 cases of CCHF a year from southern regions. Molecular surveillance of CCHFV is crucial to implement effective prevention and control strategies, understand viral evolution, study transmission dynamics, and develop effective diagnostics, therapeutics, and vaccines. While the presence of Asia-1 and Asia-2 genotypes has been previously reported, only two historical samples from Tajikistan have been fully sequenced. In this study we developed and applied a genotype IV-specific tiling PCR enrichment approach recovering 52 CCHFV genome segment sequences from clinical and Hyalomma tick samples collected between 2017-2023. Most sequences belonged to the Asia-2 genotype, but one virus exhibited an Asia-1 S segment combined with Asia-2 M and L segments, representing the first evidence of such viral reassortment event in Tajikistan.

Indexed as

Genome, ViralHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoReassortant VirusesAnimalsGenotypeHumansPhylogenyTajikistan

Identifiers

PMID41945610
PMCPMC13075792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.