Evidence map›Paper›PMID 41945450›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Antagonism by the type VI secretion system of

Leila Tuzlak, Téa E Pappas, Michael J Coyne, Madeline L Sheahan, Victoria Burgo, Phoebe A Rice, Laurie E Comstock

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Leila Tuzlak *Duchossois Family Institute University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7989-7938
Téa E Pappas *Duchossois Family Institute University of Chicago, Chicago, IL 60637.ORCID 0009-0006-7423-9286
Michael J CoyneDuchossois Family Institute University of Chicago, Chicago, IL 60637.ORCID 0009-0007-8456-213X
Madeline L SheahanDuchossois Family Institute University of Chicago, Chicago, IL 60637.ORCID 0009-0008-3152-8381
Victoria BurgoDuchossois Family Institute University of Chicago, Chicago, IL 60637.
Phoebe A RiceCommittee on Microbiology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-3467-341X
Laurie E ComstockDuchossois Family Institute University of Chicago, Chicago, IL 60637.ORCID 0009-0002-6368-8351

Funding

Secreted antimicrobial proteins of the intestinal BacteriodalesR01AI093771 · NIAID · UNIVERSITY OF CHICAGO · PI LAURIE E COMSTOCK · 2012 to 2026
$5.1M
Molecular and Cellular Biology Training ProgramT32GM144292 · NIGMS · UNIVERSITY OF CHICAGO · PI Demet Arac-Ozkan, BENJAMIN S GLICK · 2022 to 2026
$4.1M
Machinery of the Microbial MobilomeR35GM149586 · NIGMS · UNIVERSITY OF CHICAGO · PI PHOEBE A RICE · 2023 to 2026
$1.8M
HHS | National Institutes of Health (NIH) R01AI093771HHS | National Institutes of Health (NIH) R35GM149586NIAID NIH HHS R01 AI093771NIGMS NIH HHS R35 GM149586NIGMS NIH HHS T32 GM144292NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) 2140001
6 · The paper itself

Abstract

Antagonistic systems of bacteria are often tightly regulated. The human gut Bacteroidales harbor three distinct antagonistic type VI secretion systems (T6SS), one of which is present only in

Indexed as

Bacterial ProteinsBacteroides fragilisType VI Secretion SystemsAnimalsGene Expression Regulation, BacterialQuorum SensingBacterial ProteinsType VI Secretion SystemsantagonismBacteroidesmicrobiotaT6SSTetR

Identifiers

PMID41945450
PMCPMC13080023

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.