ArticleProceedings of the National Academy of Sciences of the United States of America2026
A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen.
Alexander J McClelland, Bin Hu, Yuantao Xu, Xiaodong Fang, Chunxia Wang, Benjamin L Koch, Amelia H Lovelace, Eva Hawara, Yuanchun Wang, Zhiqian Pang and 8 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
18 authors.
Alexander J McClelland *The Sainsbury Laboratory, University of East Anglia, Norwich NR4 7UH, United Kingdom.ORCID 0000-0003-1908-2643 Bin Hu *National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan 430070, China.
Yuantao XuNational Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan 430070, China.
Xiaodong FangThe Sainsbury Laboratory, University of East Anglia, Norwich NR4 7UH, United Kingdom.
Chunxia WangCitrus Research and Education Center, Department of Plant Pathology, Microbiology and Cell Science, University of Florida/Institute of Food and Agricultural Sciences, Lake Alfred, FL 33850.ORCID 0000-0003-3890-8973 Benjamin L KochThe Sainsbury Laboratory, University of East Anglia, Norwich NR4 7UH, United Kingdom.ORCID 0000-0003-3239-9733 Amelia H LovelaceThe Sainsbury Laboratory, University of East Anglia, Norwich NR4 7UH, United Kingdom.ORCID 0000-0002-6793-7493 Eva HawaraDepartment of Microbiology and Plant Pathology, University of California Riverside, Riverside, CA 92521.
Yuanchun WangCitrus Research and Education Center, Department of Plant Pathology, Microbiology and Cell Science, University of Florida/Institute of Food and Agricultural Sciences, Lake Alfred, FL 33850.
Zhiqian PangCitrus Research and Education Center, Department of Plant Pathology, Microbiology and Cell Science, University of Florida/Institute of Food and Agricultural Sciences, Lake Alfred, FL 33850.
Agustina De FrancescoDepartment of Microbiology and Plant Pathology, University of California Riverside, Riverside, CA 92521.
Suzanne P van WierSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0009-0003-5048-5237 Andrew M BeekmanSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0000-0002-3056-6406 Amit LevyCitrus Research and Education Center, Department of Plant Pathology, Microbiology and Cell Science, University of Florida/Institute of Food and Agricultural Sciences, Lake Alfred, FL 33850.
Nian WangCitrus Research and Education Center, Department of Plant Pathology, Microbiology and Cell Science, University of Florida/Institute of Food and Agricultural Sciences, Lake Alfred, FL 33850.ORCID 0000-0001-7743-0728 Renier A L van der HoornPlant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford OX1 3RB, United Kingdom.ORCID 0000-0002-3692-7487 Qiang XuNational Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-1786-9696 Funding
Citrus Research and Development Foundation (CRDF) FLA-CRC-005979EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC) 101019324Gatsby Charitable Foundation (GATSBY) WMAMOST | National Natural Science Foundation of China (NSFC) 32525008MOST | National Natural Science Foundation of China (NSFC) U23A20198UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BBS/E/J/000PR9797UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/W00691X/1USDA | National Institute of Food and Agriculture (NIFA) 2020-70029-33197USDA | National Institute of Food and Agriculture (NIFA) 2022-70029-38471USDA | National Institute of Food and Agriculture (NIFA) 2023-70029-41280
6 · The paper itselfAbstract
Plants secrete a variety of proteases as a defense response during infection by microbial pathogens. However, the relationship between their catalytic activities and antimicrobial functions remains largely unknown. Particularly, few biologically relevant substrates of these proteases have been identified. Huanglongbing (HLB) has been a major threat to the citrus industry worldwide. The HLB-associated bacterium, "
Indexed as
Bacterial Outer Membrane ProteinsCitrusLiberibacterPeptide HydrolasesPlant DiseasesCysteine ProteasesBacterial Outer Membrane ProteinsCysteine ProteasesPeptide Hydrolasesbacterial pathogensCandidatus Liberibactercitrus greening diseaseplant innate immunityplant-pathogen interactions
Identifiers
PMID41945448
PMCPMC13079941
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