Evidence map›Paper›PMID 41945189›Full record

ArticleTransgenic research2026

Generation and characterization of the Il11-Cre knock-in mouse.

Xuetao Zhou, Zhongliang Xie, Wenjia Liu, Qingye Wang, Huisang Lin, Rongyu Li, Yiming Lang, Jun Chen, Xiao Yang, Yan Teng and 1 more

Abstract read
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In one paragraph

Article in Transgenic research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuetao Zhou *College of Life Sciences, Hebei University, Baoding, 071002, China.
Zhongliang Xie *College of Life Sciences, Hebei University, Baoding, 071002, China.
Wenjia Liu *State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Qingye WangState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Huisang LinState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Rongyu LiState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Yiming LangState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Jun ChenState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Xiao YangState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China.
Yan TengState Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, China. yanteng@bmi.ac.cn.
Guan YangCollege of Life Sciences, Hebei University, Baoding, 071002, China. yangguan@bmi.ac.cn.

Funding

Independent Research Program of the State Key Laboratory of Proteomics SKLP-K202004National Center for Protein Science (Beijing) Main Facility Technology Innovation Open Sharing Project 2023-NCPSB-003National Key Research and Development Program of China 2021YFA1301604National Natural Science Foundation of China 32470854
6 · The paper itself

Abstract

Interleukin-11 (Il11) is a cytokine that belongs to the IL-6 family and is involved in inflammation, fibrosis, cancer, and ageing. Here, we generated an Il11-Cre knock-in mouse line and crossed it with the R26-tdTomato reporter to label and track of Il11-positive cells and their descendants under both developmental and pathological conditions. Using multicolor immunofluorescence staining, we identified tdTomato cells in various cell types, including fibroblasts and osteoblasts in bone, neurons in brain, enteroendocrine cells and fibroblasts in the gastrointestinal tract, pancreatic β-cells, and serous acinar cells in the submandibular glands. Notably, we observed a significant increase in fibroblasts labelled by tdTomato in a colitis model. These results indicate that this Il11-Cre line can serve as a useful genetic tool for genetic manipulation studies based on the Cre-loxp system in the aforementioned cells.

Indexed as

ColitisGene Knock-In TechniquesIntegrasesInterleukin-11AnimalsEnteroendocrine CellsFibroblastsLuminescent ProteinsMiceMice, TransgenicNeuronsOsteoblastsCre recombinaseIntegrasesInterleukin-11Luminescent ProteinsCre miceGene expressionInterleukin-11Knock-in

Identifiers

PMID41945189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.