Evidence map›Paper›PMID 41945001›Full record

ArticleAnnals of biomedical engineering2026

Aortic Valve Phenotype Shapes Helical Flow in the Ascending Aorta: Insights from 4D Flow MRI.

Karol Calò, Andrea Guala, Valentina Mazzi, Lydia Dux-Santoy, José F Rodriguéz Palomares, Stefania Scarsoglio, Luca Ridolfi, David A Steinman, Diego Gallo, Umberto Morbiducci

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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karol CalòPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
Andrea GualaVall d'Hebron Institut de Recerca, Barcelona, Spain.
Valentina MazziPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
Lydia Dux-SantoyVall d'Hebron Institut de Recerca, Barcelona, Spain.
José F Rodriguéz PalomaresVall d'Hebron Institut de Recerca, Barcelona, Spain.
Stefania ScarsoglioPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
Luca RidolfiPolitoBIOMed Lab, Department of Environment, Land and Infrastructure Engineering, Politecnico di Torino, Turin, Italy.
David A SteinmanDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Diego GalloPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
Umberto MorbiducciPolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy. umberto.morbiducci@polito.it.ORCID http://orcid.org/0000-0002-9854-1619

Funding

European Union - Next Generation EU 2022L7KK7LInstituto de Salud Carlos III (co-founded by European Union) CP24/00121Instituto de Salud Carlos III (co-founded by European Union) PI20/01727
6 · The paper itself

Abstract

purposeHelical flow in the ascending aorta (AAo) is recognized as beneficial to cardiovascular physiology. Previous in vivo studies of bicuspid aortic valve (BAV) disease have mainly relied on qualitative assessments or surrogate measures of helical flow, hampering its use as potential hemodynamic biomarker. Here, we leveraged a rigorous fluid mechanical framework for helical flow structures to (i) determine how aortic valve (AV) phenotype-tricuspid (TAV) versus bicuspid-influences AAo helical flow and (ii) identify its principal anatomical and hemodynamic determinants.

methods4D flow MRI data from sixty subjects (41 TAV, 19 BAV) were analyzed. Helicity-derived quantities were computed to quantify the intensity and topology of AAo helical flow. Conventional hemodynamic and anatomical parameters were also extracted and their association with helicity-based quantities was explored.

resultsCompared with TAV subjects, BAV patients exhibited lower helicity intensity and reduced predisposition to form coherent helical flow patterns. In TAV, helical flow topology was primarily influenced by flow pulsatility and vessel anatomy, whereas in BAV, eccentric systolic jets promoted the arrangement of blood flow into helical structures without enhancing helicity intensity. Helical flow topology emerged as highly sensitive to AV phenotype, with its discriminative power augmented by conventional anatomical or hemodynamic parameters.

conclusionAV phenotype critically shapes helical flow in AAo through phenotype-specific anatomical and hemodynamic determinants. The eccentric jet associated with BAV disrupts helicity intensity, potentially diminishing the protective role of helical flow. Integrating conventional hemodynamic and anatomical parameters with helical flow topology yields a robust, in vivo measurable morpho-hemodynamic signature of BAV, offering diagnostic and prognostic potential.

Indexed as

AortaAortic ValveHeart Valve DiseasesAdultAgedBicuspid Aortic Valve DiseaseFemaleHemodynamicsHumansMagnetic Resonance ImagingMaleMiddle AgedPhenotype4D flow MRIAscending aortaBicuspid aortic valveHelical flowHelicityHemodynamics

Identifiers

PMID41945001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.