ArticleBulletin of experimental biology and medicine2026
Comparative Evaluation of the Protective Activity of Dibornol and Prostagenin in a Model of DNA Damage in Rat Testicular Tissue Cells.
Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The effects of alkylated phenol antioxidants, dibornol (2,6-diisobornyl-4-methylphenol) and prostagenin (4-hydroxymethyl-2,6-diisobornylphenol), on the level of DNA damage, free radical light sum, antioxidant capacity, and the redox balance of testicular cells were studied in 12-week-old male Wistar rats. Using the alkaline comet assay (single-cell gel electrophoresis), we demonstrated that the substituted phenols effectively reduce DNA damage in rat testicular cells, exhibiting comparable genoprotective efficacy. Chemiluminescence analysis demonstrated that testicular tissue cells were sensitive to the antioxidant effects of both compounds. However, based on the antioxidant defense and redox parameters, prostagenin exhibited superior activity. Specifically, prostagenin administration shifted the cellular redox balance toward a more reduced state.
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