Evidence map›Paper›PMID 41944949›Full record

ArticleBulletin of experimental biology and medicine2026

Comparative Analysis of the Effect of Uridine on Oxidative and Energy Metabolism in the Blood during Administration of Rotenone and 6-Hydroxydopamine in Rats.

N V Khunderyakova, T V Polyakova, V P Medvedeva, I V Bulgin, A E Malkov, V V Mironov, N V Khmil, A G Medentsev, G D Mironova

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

N V KhunderyakovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. nkhunderyakova@gmail.com.
T V PolyakovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
V P MedvedevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
I V BulginInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
A E MalkovInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
V V MironovInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
N V KhmilInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
A G MedentsevG. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Russia.
G D MironovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effect of the nucleoside uridine on the activities of key enzymes of oxidative phosphorylation (succinate dehydrogenase, SDH) and glycolysis (lactate dehydrogenase, LDH) in peripheral blood lymphocytes, and on oxidative metabolism in the blood serum of rats in the rotenone and 6-OHDA models of Parkinson's disease. Both models were characterized by increased SDH and LDH activities in lymphocytes and accumulation of lipid peroxides in the blood serum. Injections of uridine, affecting the functioning of mitochondrial K-ATP channel (mitoKATP), to animals at a dose of 30 mg/kg body weight for 28 days mitigated SDH and LDH hyperactivation in lymphocytes and reduced the serum level of LPO products. Specific mitoKATP inhibitor 5-hydroxydecanoate (5 mg/kg) eliminated the effect of uridine. The role of mitoKATP in the protective effect of uridine in a model of Parkinson's disease is discussed.

Indexed as

Energy MetabolismOxidopamineRotenoneUridineAnimalsDecanoic AcidsHydroxy AcidsLipid PeroxidationL-Lactate DehydrogenaseLymphocytesMaleOxidative PhosphorylationPotassium ChannelsRatsRats, WistarSuccinate Dehydrogenase5-hydroxydecanoic acidDecanoic AcidsHydroxy AcidsL-Lactate Dehydrogenasemitochondrial K(ATP) channelOxidopaminePotassium ChannelsRotenoneSuccinate DehydrogenaseUridinelactate dehydrogenaselymphocytesParkinson’s diseaserotenonesuccinate dehydrogenase

Identifiers

PMID41944949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.