Expression of IL-1β in the Left-Ventricular Myocardium of Rats with Insulin-Dependent Diabetes Mellitus and Its Combination with Arterial Hypertension.

A P Sklifasovskaya, M L Blagonravov, V A Goryachev, M M Azova

Abstract read

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

A P SklifasovskayaPeoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia. a.sklifasovskaya91@gmail.com.

M L BlagonravovPeoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia.

V A GoryachevPeoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia.

M M AzovaPeoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we evaluated the level of proinflammatory cytokine IL-1β in left-ventricular myocardium of rats with arterial hypertension at different periods, insulin-dependent diabetes mellitus, and a combination of these conditions. We found that IL-1β expression in the left ventricle was significantly increased in isolated diabetes mellitus, 57-week arterial hypertension, and combination of 38-week arterial hypertension and diabetes mellitus. In the group with 38-week arterial hypertension, IL-1β expression also exceeded the control level (normotensive rats), but the shifts were less pronounced. Increased IL-1β production in the myocardium can be considered a mechanism triggering inflammatory programmed death (pyroptosis) of cardiomyocytes.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Heart VentriclesHypertensionInterleukin-1betaMyocardiumAnimalsMaleMyocytes, CardiacRatsRats, WistarInterleukin-1betaarterial hypertensiondiabetes mellitusinflammasome NLRP3interleukin-1βpyroptosis

Identifiers

PMID41944946

DOI10.1038/ni.3659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.