Evidence map›Paper›PMID 41944940›Full record

ArticleBulletin of experimental biology and medicine2026

Cardioprotective Effect of Endomorphin-1 In Vitro: the Role of Intracellular Messengers.

B K Kurbatov, A S Gorbunov, A V Mukhomedzyanov, S V Popov, N V Naryzhnaya, M Kilin, L N Maslov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

B K KurbatovCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A S GorbunovCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A V MukhomedzyanovCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. sasha_m91@mail.ru.
S V PopovCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
N V NaryzhnayaCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
M KilinCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
L N MaslovCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global ischemia (45 min) followed by reperfusion (30 min) was modeled in isolated hearts from male Wistar rats. A selective μ2-opioid receptor agonist endomorphin-1 (152 nmol/liter) was added to the perfusate at the onset of reperfusion. Myocardial levels of inositol triphosphate and diacylglycerol were measured. It was found that endomorphin-1 improved cardiac contractility parameters during reperfusion. Furthermore, perfusion with a solution containing endomorphin-1 increased myocardial inositol triphosphate and diacylglycerol concentrations by 4.1 and 6 times, respectively. Hence, stimulation of cardiac μ2-opioid receptors increases cardiac tolerance to reperfusion injury.

Indexed as

Cardiotonic AgentsMyocardial Reperfusion InjuryOligopeptidesAnimalsHeartMaleMyocardial ContractionMyocardiumRatsRats, WistarReceptors, Opioid, muCardiotonic Agentsendomorphin 1OligopeptidesReceptors, Opioid, muendomorphin-1heartischemia/reperfusionopioid receptors

Identifiers

PMID41944940

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.