Evidence map›Paper›PMID 41944729›Full record

ArticleJournal of cachexia, sarcopenia and muscle2026

Myonuclear Domain-Associated and Central Nucleation-Dependent Spatial Restriction of Dystrophin Protein Expression.

Katarzyna Chwalenia, Vivi-Yun Feng, Nicole Hemmer, John C W Hildyard, Liberty E Roskrow, Richard J Piercy, Eric T Wang, Annemieke Aartsma-Rus, Maaike van Putten, Matthew J A Wood and 1 more

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Article in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katarzyna ChwaleniaDepartment of Paediatrics, University of Oxford, Oxford, UK.
Vivi-Yun FengDepartment of Paediatrics, University of Oxford, Oxford, UK.
Nicole HemmerDepartment of Paediatrics, University of Oxford, Oxford, UK.
John C W HildyardComparative Neuromuscular Diseases Laboratory, Department of Clinical Science and Services, Royal Veterinary College, London, UK.ORCID 0000-0003-2283-2118
Liberty E RoskrowComparative Neuromuscular Diseases Laboratory, Department of Clinical Science and Services, Royal Veterinary College, London, UK.ORCID 0009-0006-3578-5962
Richard J PiercyComparative Neuromuscular Diseases Laboratory, Department of Clinical Science and Services, Royal Veterinary College, London, UK.ORCID 0000-0002-4344-6438
Eric T WangDepartment of Molecular Genetics & Microbiology, Center for NeuroGenetics, Genetics Institute, University of Florida, Gainesville, Florida, USA.
Annemieke Aartsma-RusDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0003-1565-654X
Maaike van PuttenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-0683-8897
Matthew J A WoodDepartment of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0002-5436-6011
Thomas C RobertsDepartment of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0002-3313-7631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe restoration of uniformly distributed dystrophin protein expression is an important consideration for the development of advanced therapeutics for Duchenne muscular dystrophy (DMD).

methodsWe have generated a novel genetic mouse model (mdx52-Xist

resultsTotal dystrophin expression increased by ~2.8-fold (p < 0.010) in aged (60-week-old) mdx52-Xist

conclusionsThese findings reveal new insights into the importance of dystrophin spatial localization and identify a previously unappreciated barrier to effective therapeutic dystrophin restoration, particularly within regenerated or centrally nucleated myofibers.

Indexed as

DystrophinMuscular Dystrophy, DuchenneAnimalsDisease Models, AnimalFemaleMiceMice, Inbred mdxMuscle, SkeletalDystrophincentral nucleationDMDdystrophinmyonuclear domainX‐chromosome inactivation

Identifiers

PMID41944729
PMCPMC13055465

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.