Evidence map›Paper›PMID 41944648›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Bioinspired, Mitochondria-Targeted Single-Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​.

Yuwen Wang, Xinzhi Liang, Tiandi Xiong, Zheng Zhong, Ning Zhang, Boguang Yang, Dong Li, Qiongjiao Zeng, Xian Chen, Yiting Lei and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yuwen WangDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID https://orcid.org/0000-0002-7612-7935
Xinzhi LiangDepartment of Orthopedic Surgery, Center For Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.
Tiandi XiongDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Zheng ZhongDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Ning ZhangDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Boguang YangDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Dong LiDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Qiongjiao ZengDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Xian ChenDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Yiting LeiDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Shangsi ChenDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Chao ZhengInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Liu YangInstitute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Wei HuangDepartment of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Rocky S TuanDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Denghui XieDepartment of Orthopedic Surgery, Center For Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.
Zhong Alan LiDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong, China.ORCID https://orcid.org/0000-0002-6009-629X

Funding

Center for Neuromusculoskeletal Restorative Medicine, Health@InnoHK program, Innovation and Technology Commission, Hong Kong SARHong Kong Research Grants Council 24203523National Natural Science Foundation of China 82302753National Natural Science Foundation of China 82372358Natural Science Foundation for Distinguished Young Scholars of Guangdong Province 2022B1515020044Shun Hing Institute of Advanced Engineering BME-p2-24
6 · The paper itself

Abstract

Normal mitochondrial function in stem cells is essential for effective bone regeneration, with mitochondrial complex IV (cytochrome c oxidase, CcO) playing a crucial role in sustaining electron transport chain activity and ATP synthesis. To address mitochondrial dysfunction associated with bone defects, we developed a dendritic mesoporous silica nanoparticle (DMSN)-based, CcO-mimetic nanozyme, named triphenylphosphonium (TPP)-DMSN-Fe/Cu. The nanozyme incorporated iron and copper single atoms to mimic the catalytic center of CcO and is modified with the mitochondria-targeting agent TPP. In vitro, TPP-DMSN-Fe/Cu nanozymes colocalized with mitochondria and enhanced mitochondrial function, effectively regulating cellular energy metabolism and promoting stem cell osteogenesis. In vivo, TPP-DMSN-Fe/Cu nanozymes resulted in significantly enhanced bone regeneration compared to the control, resulting in a 177% increase in bone volume and a 12% increase in mineral density at critical-sized bone defects in rats after 4 weeks of treatment. Taken together, these findings demonstrate that bioinspired, mitochondria-targeting TPP-DMSN-Fe/Cu nanozymes hold strong promise for accelerating bone regeneration via regulating cellular energy metabolism.

Indexed as

Biomimetic MaterialsBone RegenerationEnergy MetabolismMitochondriaNanoparticlesStem CellsAnimalsCell DifferentiationCopperElectron Transport Complex IVIronOsteogenesisRatsSilicon DioxideCopperElectron Transport Complex IVIronSilicon Dioxidebone regenerationmitochondrial energy metabolismnanoparticlesosteogenic differentiationstem cells

Identifiers

PMID41944648
PMCPMC13155285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.