ArticleAnesthesiology2026
Gabapentin and Opioid Prescribing Trends among Adolescents Undergoing Common Procedures: A National Retrospective Cohort Study.
Article in Anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAdolescents who fill an opioid prescription for surgery are at increased risk of adverse outcomes, including persistent opioid use, addiction, or overdose. Limited evidence suggests clinicians may increasingly prescribe gabapentin as an opioid-sparing strategy, although gabapentin is increasingly associated with adverse outcomes. The authors examined perioperative gabapentin and opioid prescribing trends over time.
methodsUsing a national private insurance claims database, the authors identified a cohort of gabapentin and opioid-naive adolescents 11 to 21 yr old who underwent seven procedures that are either common or associated with postoperative persistent opioid use between 2012 and 2022. The authors quantified initial gabapentin and opioid prescriptions, refills within 60 days, and number of days and pills dispensed and used multivariable logistic regression analysis to assess the association between gabapentin dispensing and opioid refills.
resultsOf 181,225 gabapentin and opioid-naive adolescents, 32.1% (n = 58,139) filled a new prescription for one or both. Specifically, 1.1% (n = 662) filled a gabapentin prescription, 96.7% (n = 56,210) filled an opioid prescription, and 2.2% (n = 1,267) filled both. Initial gabapentin prescriptions included a mean ± SD supply of 22.0 ± 15.0 days, 55.3% contained an initial daily dose 600 mg or greater, and 36.5% obtained one or more refills. Opioid-only prescriptions declined during the study period, while gabapentin prescriptions with and without opioid increased. Adolescents who filled both opioid and gabapentin versus opioid-only prescriptions had a 14% (95% CI, 11.0 to 16.8%) adjusted probability difference with regard to obtaining an opioid refill (40.7% vs. 21.6%).
conclusionsGabapentin dispensing increased over time, and more than one third of adolescents were dispensed a refill prescription. Coprescription with opioids did not appear to be associated with decreased opioid quantity in the initial prescription or decreased likelihood of obtaining a refill opioid prescription after undergoing a study procedure. In addition, opioids were often prescribed when they were unlikely to be needed for postoperative pain management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.