Observational studyColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2026
Mild to moderate frailty among older adults does not affect long-term quality of life or functional outcomes after colon cancer surgery.
Observational study in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Frailty and colon cancer surgery: Accounting for survivorship bias in patient-reported outcomes.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundFrailty is known to adversely affect post-operative mortality and morbidity following colorectal cancer resection, but its impact on long-term quality of life and functional outcomes after colon cancer surgery is less clear. This study aims to evaluate the impact of frailty at the time of diagnosis on quality of life, impact on daily activities, and contentment with treatment one year after colon cancer resection.
methodData were obtained from the prospective, multicentre Quality of Life in Colon Cancer (QoLiCOL) study. Patients aged ≥70 years who underwent colon cancer surgery in Region Västra Götaland, Sweden, were collected from the QoLiCOL database (n = 347). Clinical data were retrieved from national quality registries. Frailty was retrospectively assessed by reviewing medical records using the Clinical Frailty Scale-9 (CFS-9), with scores ≥4 classified as frail. Outcomes included self-reported quality of life, treatment-related impact on activities of daily living, and treatment satisfaction one year post-operatively. Directed Acyclic Graphs (DAGs) of variables known to affect the outcome variables were made before analyses, and potential confounders were adjusted for in the final analyses. Comparisons between frail and non-frail groups were performed using ordinal logistic regression and logistic regression, with results reported as odds ratios (OR).
resultsThe prevalence of frailty in the cohort was 29%, with a median CFS-9 value of 4 (range 4-6) in the frail group, indicating very mild to moderate frailty. No significant differences were observed between frail and non-frail older adults in self-assessed quality of life, treatment-related impact on daily activities or treatment satisfaction one year after surgery. Notably, both groups reported improved quality of life at one year compared with baseline. Only a small proportion of participants (n = 8; 2%) reported not being content with their treatment.
conclusionAmong older adults who were alive one year after colon cancer surgery, mild to moderate frailty does not appear to negatively influence long-term quality of life, effect on daily activities, or satisfaction with treatment. Frail and non-frail patients reported similar levels of well-being and contentment with their care one year post-operatively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.