Evidence map›Paper›PMID 41944313›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Biolipid Film-Fused Electrochemiluminescence for Multipurpose In Situ Bioassays.

Jialiang Chen, Bin Li, Yingying Wang, Fulin Zhu, Wenxuan Yang, Xuanyu Fu, Tiantian Man, Qiuyue Wu, Kewei Ren, Shengyuan Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jialiang ChenSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
Bin LiSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
Yingying WangSchool of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, China.
Fulin ZhuSchool of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, China.
Wenxuan YangSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
Xuanyu FuSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
Tiantian ManSchool of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, China.
Qiuyue WuSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
Kewei RenSchool of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China.
Shengyuan DengSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.ORCID https://orcid.org/0000-0002-6382-0976

Funding

Fundamental Research Funds for the Central Universities 2025201001Fundamental Research Funds for the Central Universities 30924010201Fundamental Research Funds for the Central Universities 30924010809National Natural Science Foundation of China 22204077National Natural Science Foundation of China 22374076National Natural Science Foundation of China 22504061Natural Science Foundation of Jiangsu Province BK20231455Open Research Program of National Major Scientific and Technological Infrastructure for Translational Medicine TMSK-2024-115Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX24_0688State Key Laboratory of Analytical Chemistry for Life Science SKLACLS2402State Key Laboratory of Analytical Chemistry for Life Science SKLACLS2412
6 · The paper itself

Abstract

Electrochemiluminescence (ECL) is intrinsically a surface-state-sensitive strategy, yet its seamless synergy with soft biomembranes remains sparsely explored. Herein, a biolipid-bound, membrane-interactive scaffold is built upon an ECL-emissive artificial nanochannel and smoothly blended into supported phospholipid bilayers containing cholesterol and diversified natural or synthetic lipids. Such bilayer-bridged assemblies preserve efficient emission while permitting dynamic membrane remodeling. The resulting biointerface enables label-free profiling of cytomembrane-active species, including divalent cations, amphiphilic pharmaceuticals, and pore-forming peptides, through real-time isotherm and kinetic analysis. By further integrating phospholipid-pendant recognition motifs, femtomolar detection of Alzheimer's disease biomarkers (β-amyloid polypeptide and tau protein) is achieved. Moreover, vesicle-mediated membrane merging embeds ECL emitters into living-cell plasmalemma, affording surface-confined single-cell visualization using endogenous oxygen as the coreactant. Collectively, this biointerface-compatible ECL paradigm enables multiplexed monitoring of molecular, membranous, and cellular processes via membrane-structural modulation.

Indexed as

Alzheimer DiseaseBiological AssayBiosensing TechniquesElectrochemical TechniquesLipid BilayersLuminescent MeasurementsPhospholipidsAmyloid beta-PeptidesHumansAmyloid beta-PeptidesLipid BilayersPhospholipidsbilayer‐bridged biomembrane mimicschannel‐confined cytomembrane chemistryelectrochemiluminescence‐enabled biointerfacessurface‐state‐sensitive signal transductionvesicle‐merged single‐cell visualization

Identifiers

PMID41944313
PMCPMC13317783

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.