Evidence map›Paper›PMID 41944309›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP-Mediated Invasion Activates Ras Signaling and Destabilizes p53.

Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhen WangDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Jia ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Haojie LuDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Jingjing NiDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Shuaishuai YangDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Yuting ShiDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Shuo ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.
Pei ZhangInstitutional Center For Shared Technologies and Facilities of Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, P. R. China.
Li LiuDepartment of Epidemiology and Biostatistics, School of Public Health, Ministry of Education Key Lab of Environment and Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China.ORCID https://orcid.org/0000-0001-7455-1735

Funding

National Natural Science Foundation of China 82173602National Natural Science Foundation of China 82473713
6 · The paper itself

Abstract

Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC-associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues. In vitro and in vivo experiments elucidated the oncogenic effects of Gemella morbillorum on human CRC cell lines and mouse models. Multimodal imaging shows that Gemella morbillorum can internalize into host cells. RNA sequencing, co-immunoprecipitation, and mass spectrometry identified that Gemella morbillorum invades host cells via interaction between its LysM peptidoglycan-binding domain protein (LPBDCP) and host cell surface transmembrane protein TMEM140. This invasion triggers Ca

Indexed as

CarcinogenesisColorectal Neoplasmsras ProteinsTumor Suppressor Protein p53AnimalsHumansMiceSignal Transductionras ProteinsTumor Suppressor Protein p53Ca2+colorectal cancerGemella morbillorump53RASA4

Identifiers

PMID41944309
PMCPMC13285141

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.