Evidence map›Paper›PMID 41944302›Full record

ArticleBiopharmaceutics & drug disposition2026

Improvement of XZP8257 Dissolution Properties Through Amorphous and Mixed-Phase Precipitate Formation in Biorelevant Media.

Miao Zhang, Shudong Zhang, Bin Wu, Zhe Zhang, Qin Hu, Lin Wang, Dongyang Liu

Abstract read
In one paragraph

Article in Biopharmaceutics & drug disposition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miao ZhangDrug Clinical Trial Center, Peking University Third Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-6132-133X
Shudong ZhangNMPA Key Laboratory for Research and Evaluation of Generic Drugs, Beijing Institute for Drug Control, Beijing, China.
Bin WuNMPA Key Laboratory for Research and Evaluation of Generic Drugs, Beijing Institute for Drug Control, Beijing, China.
Zhe ZhangNMPA Key Laboratory for Research and Evaluation of Generic Drugs, Beijing Institute for Drug Control, Beijing, China.
Qin HuNMPA Key Laboratory for Research and Evaluation of Generic Drugs, Beijing Institute for Drug Control, Beijing, China.
Lin WangNMPA Key Laboratory for Research and Evaluation of Generic Drugs, Beijing Institute for Drug Control, Beijing, China.
Dongyang LiuDrug Clinical Trial Center, Peking University Third Hospital, Beijing, China.ORCID https://orcid.org/0000-0002-0608-8192

Funding

National Natural Science Foundation of China 82173895
6 · The paper itself

Abstract

Although precipitation of poorly soluble drugs in the gastrointestinal (GI) tract is often considered detrimental to bioavailability, the solid-state nature of the precipitate, either crystalline or amorphous, may critically redefine its impact. Contrasting with reported crystalline precipitates of weakly basic drugs, this study investigates XZP8257 (C

Indexed as

Pharmaceutical PreparationsBile Acids and SaltsChemical PrecipitationCrystallizationHydrogen-Ion ConcentrationSolubilityBile Acids and SaltsPharmaceutical Preparationsamorphous formcrystalline‐amorphous mixturephysicochemical propertiesprecipitatesweakly acidic drug

Identifiers

PMID41944302
PMCPMC13471972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.