Evidence map›Paper›PMID 41944220›Full record

ArticleAging cell2026

Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration.

Jianfeng Yu, Mingzhuang Hou, Yaoge Deng, Chenqi Yu, Yang Liu, Kang Kang, Xiaowei Xia, Xiaoping Li, Huilin Yang, Dinghua Jiang and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT07567378. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07567378 not yet recruiting

Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition Subcohort

Ran2026Enrolled30Registered outcomes14Posted comparisons0ConditionsAtrial Fibrillation (AF), Coronary Artery Disease, Diabetes (DM), Heart FailureArmsTirzepatide
PMID 41406444PMID 40903131PMID 41666927PMID 38878772PMID 39566869PMID 28701474PMID 41928037PMID 42010357PMID 32154773PMID 30170852PMID 41903163other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianfeng YuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Mingzhuang HouDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yaoge DengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Chenqi YuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yang LiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Kang KangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xiaowei XiaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xiaoping LiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.ORCID 0000-0002-9459-7981
Dinghua JiangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Wu XuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Yijian ZhangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Xuesong ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.ORCID 0000-0003-3579-2741

Funding

Basic Research Pilot Project Suzhou SSD2024062Basic Research Pilot Project Suzhou SSD2025026China Postdoctoral Science Foundation 2024M762313China Postdoctoral Science Foundation 2025T180666Key Project of Jiangsu Health Commission K2023079National Key R&D Program of China 2022YFC2502902National Natural Science Foundation of China 82272494National Natural Science Foundation of China 82402864National Natural Science Foundation of China 82472452Natural Science Foundation of Jiangsu Province BK20240368Natural Science Foundation of Jiangsu Province BK20250353Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)Suzhou Applied Basic Research (Medical and Health) SYW2024076
6 · The paper itself

Abstract

In the context of population aging, musculoskeletal fitness has emerged as a cornerstone of overall well-being and injury prevention, relying on the coordinated function of cartilage, bone, and muscle. Drawing on the principle of "increasing income and reducing expenditure," we propose a combinatorial formulation consisting of the nicotinamide adenine dinucleotide (NAD) precursor nicotinamide mononucleotide (NMN) and the NAD

Indexed as

Cellular SenescenceNADRegenerationAnimalsHumansMaleMiceNADapigenincellular senescencemusculoskeletal disordersnicotinamide adenine dinucleotidenicotinamide mononucleotidephytosphingosine

Identifiers

PMID41944220
PMCPMC13054677

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.