ReviewJournal of the American Heart Association2026
Iron Dysregulation and Vascular Diseases: A Contemporary Review.
Review in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Mechanotransduction in Marfan Syndrome and Related Aortic Disorders: Insights from Transcriptomic Analyses.Genes · 2026Review
- Iron Compartmentalisation and Vascular Endothelial Cell Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
- Mechanisms of vascular calcification: cellular phenotype switching drives matrix remodeling and mineralized microenvironment formation.Frontiers in cardiovascular medicine · 2026Review
- Phase angle as a potential marker of early nutritional and metabolic changes following metabolic bariatric surgery: a retrospective study.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Iron is essential for the cardiovascular system to maintain its function. Disruption of iron balance, in the form of either iron deficiency or overload, has been increasingly recognized to be linked to the pathogenesis of cardiovascular disease. The consequences of iron dysregulation in specific vascular cell types, such as endothelial cells, vascular smooth muscle cells, and macrophages, contribute to critical processes, including inflammation, oxidative stress, and vascular remodeling. In this review, we focus on the role of iron imbalance in the pathogenesis of vascular diseases, in particular atherosclerosis and aortic aneurysm. We provide an overview of cellular and systemic iron homeostasis, explore the impact of iron dysregulation on vascular cell biology, and discuss mechanistic insights into iron imbalance-induced vascular pathology. We also summarize potential therapeutic approaches targeting iron metabolism, review ongoing clinical trials, and outline future research directions needed to translate these findings into clinical interventions for vascular disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.