Evidence map›Paper›PMID 41944112›Full record

ArticleCurrent topics in medicinal chemistry2026

Antiviral Activity of Synthetic Bis-Naphthoquinone (H-5) against Chikungunya Virus Replication.

Max Willian Lisboa Gomes, Priscilla Esteves de Assis, Victoria Maranhao, Rafaela Dos Santos Pereira, Claudio Cesar Cirne-Santos, Kíssila Rabelo, Jorge Jose de Carvalho, Daniel Tadeu Gomes Gonzaga, Fernando de Carvalho da Silva, Vitor Francisco Ferreira and 2 more

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Article in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Max Willian Lisboa GomesPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, 24020-141, Niterói, RJ, Brasil.
Priscilla Esteves de AssisPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, 24020-141, Niterói, RJ, Brasil.
Victoria MaranhaoLaboratório de Virologia Molecular e Biotecnologia, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, 24020-141, RJ, Brasil.
Rafaela Dos Santos PereiraDepartamento de Biologia Celular e Molecular, Universidade Federal Fluminense, Niterói, Brazil.
Claudio Cesar Cirne-SantosPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, 24020-141, Niterói, RJ, Brasil.
Kíssila RabeloLaboratório de Ultraestrutura e Biologia Tecidual (LUBT), Departamento de Histologia e Embriologia, Universidade Estadual do Rio de Janeiro, UERJ, Rio de Janeiro, Brazil.
Jorge Jose de CarvalhoLaboratório de Ultraestrutura e Biologia Tecidual (LUBT), Departamento de Histologia e Embriologia, Universidade Estadual do Rio de Janeiro, UERJ, Rio de Janeiro, Brazil.
Daniel Tadeu Gomes GonzagaDEPFARMFCBS, Universidade do Estado do Rio de Janeiro, Campus Zona Oeste, 23070-200 Rio de Janeiro-RJ, Brazil.
Fernando de Carvalho da SilvaDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-141 Niterói-RJ, Brazil.
Vitor Francisco FerreiraDepartamento de tecnologia farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, 24241-002 Niterói-RJ, Brazil.
Caroline de Souza BarrosPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, 24020-141, Niterói, RJ, Brasil.
Izabel Christina Palmer PaixaoPrograma de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, 24020-141, Niterói, RJ, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe chikungunya virus (CHIKV) is a significant public health concern, as it is one of the most critical re-emerging infections and still lacks specific treatment or vaccination measures.

methodsIn this study, bis-naphthoquinone (H-5) was tested in CHIKV-infected cells and mice. Several techniques were employed to understand the drug's mechanism of action.

resultsCytotoxicity (CC50) and antiviral activity (EC50) tests revealed that H-5 presented low toxicity 1103 μM and good antiviral potential 0.96 μM. Virucidal test and time of addition of the compound to verify the mechanism of action presented good results. In vivo assays showed promise. In addition, synergism tests with Ribavirin indicated a strong synergistic effect. DISCUSSION: The antiviral effect associated with low toxicity demonstrates that the compound shows promise. In addition, the mechanism of action studies is crucial for the characterization of a good compound. Tests in mice demonstrated potential reduction of edema and favorable histological changes.

conclusionIt is concluded that H-5 is a promising antiviral candidate against CHIKV.

Indexed as

Antiviral AgentsChikungunya FeverChikungunya virusNaphthoquinonesVirus ReplicationAnimalsChlorocebus aethiopsDose-Response Relationship, DrugHumansMiceMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipVero CellsAntiviral AgentsNaphthoquinonesAlphavirusesAntiviralArbovirusCell cultureChikungunyaNaphthoquinone

Identifiers

PMID41944112

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.