Evidence map›Paper›PMID 41944089›Full record

ArticleAnnals of clinical and translational neurology2026

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study.

Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez-Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S Gurnani, Ting Fang Alvin Ang and 2 more

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joshi DookhyUniversity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-7271-2021
Michael CummingsDepartment of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Eden PriceThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Yulin LiuThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Santiago Gutierrez-GomezThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Sarah O'SheaDepartment of Neurology, Mount Sinai School of Medicine, New York, New York, USA.
Samuel FrankDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Rhoda AuThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Ashita S GurnaniThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Ting Fang Alvin AngThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Jesse MezThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1438-5442
Ludy C ShihThe Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6590-8365

Funding

TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ting Fang Alvin Ang · 2020 to 2026
$42.4M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
Cognitive heterogeneity in those with high Alzheimer's Disease RiskR01AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Rhoda Au, Vijaya B. Kolachalama · 2025 to 2026
$1.6M
Cognitive heterogeneity in those with high Alzheimer's Disease RiskR56AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2018 to 2018
$517k
CLC NIH HHS HHSN269201500001CCLC NIH HHS HHSN269201500001INHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN269201500001INHLBI NIH HHS N01-HC-25195NIA NIH HHS R01-AG016496NIA NIH HHS R01 AG062109NIA NIH HHS R01-AG062109NIA NIH HHS R56 AG062109NIA NIH HHS RF1 AG062109NIA NIH HHS U19 AG068753NIA NIH HHS U19AG068753
6 · The paper itself

Abstract

Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community-based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level. Annual incidence rates of dementia (5.0%, 95% CI [3.7%-6.4%]) and mortality (10.5%, 95% CI [8.7%-12.3%]), did not differ by sex or education level. Increased age at PD diagnosis was a significant risk factor for incident dementia and mortality. Sex may not be a significant risk factor for community-based PD dementia.

Indexed as

DementiaParkinson DiseaseAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedRisk FactorsdementiaFramingham heart studyincident dementiaParkinson's disease

Identifiers

PMID41944089
PMCPMC13358564

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.