ArticleHypertension (Dallas, Tex. : 1979)2026
Vascular Sphingosine Kinase 1 Regulates Angiotensin II-Induced Hypertension.
Ewelina Jozefczuk, Piotr Szczepaniak, Tomasz P Mikolajczyk, Ryszard Nosalski, Mateusz Dziedzic, Karol Urbanski, Emilia Wojciechowska, Grzegorz Filip, Monika Stefanska, Przemyslaw Blyszczuk and 2 more
Abstract read
In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Ewelina JozefczukDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0002-7621-2080 Piotr SzczepaniakDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0003-2622-7337 Tomasz P MikolajczykDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0002-7990-2896 Ryszard NosalskiCentre for Cardiovascular Sciences, Queen's Medical Research Institute; University of Edinburgh, United Kingdom (R.N., T.J.G., M. Siedlinski).ORCID 0000-0003-4661-8773 Mateusz DziedzicDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0002-0601-074X Karol UrbanskiDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0002-7647-9770 Emilia WojciechowskaDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.
Grzegorz FilipDepartment of Cardiovascular Surgery and Transplantology, John Paul II Hospital (G.F.), Jagiellonian University Medical College, Cracow, Poland.ORCID 0009-0008-5947-4426 Monika StefanskaDepartment of Clinical Immunology, Faculty of Medicine (M. Stefanska, P.B.), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0001-9885-7288 Przemyslaw BlyszczukDepartment of Clinical Immunology, Faculty of Medicine (M. Stefanska, P.B.), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0003-2521-3232 Tomasz J GuzikDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0002-5039-7849 Mateusz SiedlinskiDepartment of Internal Medicine, Faculty of Medicine (E.J., P.S., T.P.M., M.D., K.U., E.W., T.J.G., M. Siedlinski), Jagiellonian University Medical College, Cracow, Poland.ORCID 0000-0001-7682-6122 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundS1P (sphingosine-1-phosphate) signaling plays a key role in regulating the cardiovascular system. In experimental essential hypertension (HTN), expression of Sphk1 (sphingosine kinase 1), a key S1P-producing enzyme, is upregulated in the vasculature. Mice with global
methodsMice with targeted deletion of
resultsSMC-specific deletion of
conclusionsSMC-derived
Indexed as
Angiotensin IIHypertensionPhosphotransferases (Alcohol Group Acceptor)AnimalsBlood PressureDisease Models, AnimalMaleMesenteric ArteriesMiceMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleSphingosineSphingosine KinaseAngiotensin IIPhosphotransferases (Alcohol Group Acceptor)SphingosineSphingosine KinaseSphk1 protein, mouseangiotensin IIblood pressurehypertensionmesenteric arteriessphingosine 1-phosphate
Identifiers
PMID41944022
PMCPMC13275090
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