Evidence map›Paper›PMID 41943939›Full record

ArticlePsychological medicine2026

Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.

Danqing Huang, Zhening Liu, Wenjian Tan, Michel Sopodenkiewicz, Xiawei Liu, Jun Yang, Feiwen Wang, Weiqing Huang, Jie Yang, Yicheng Long and 1 more

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In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Danqing HuangDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Zhening LiuDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Wenjian TanDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Michel SopodenkiewiczDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.
Xiawei LiuDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Jun YangDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Feiwen WangDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Weiqing HuangDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Jie YangDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.
Yicheng LongDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital, Central South University, China.ORCID 0000-0003-4231-2136
Lena PalaniyappanDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.ORCID 0000-0003-1640-7182

Funding

Canada First Research Excellence FundChina Scholarship Council 202406370144Fonds de Recherche du Québec - Santé FRQS 366934National Natural Science Foundation of China 82071506National Natural Science Foundation of China 82201692
6 · The paper itself

Abstract

backgroundWorking memory (WM) impairment is a core cognitive deficit in schizophrenia, associated with dysfunction of large-scale brain networks, particularly the triple-network system comprising the default mode, frontoparietal, and salience networks. Given the role of environmental risks like childhood trauma (CT) in cognitive deficits, we investigated whether trauma relates to altered triple-network flexibility and WM in schizophrenia.

methodsWe enrolled 190 patients with schizophrenia (SZ) and 117 healthy controls (HCs). Among them, 162 SZ and 99 HCs underwent

resultsAmong HCs, individuals with childhood trauma showed reduced ΔTV across triple-network connections, whereas no such differences appeared in SZ. In SZ, greater ΔTV within the frontoparietal network (FPN) was correlated with lower positive symptom severity (

conclusionsOur findings highlight the central role of FPN flexibility in mediating childhood trauma's effect on working memory in schizophrenia. This outlines a key pathway through which an early environmental risk (trauma) translates into cognitive and clinical manifestations in schizophrenia.

Indexed as

Adverse Childhood ExperiencesCognitive DysfunctionFrontal LobeMemory, Short-TermParietal LobeSchizophreniaAdultCognitive FlexibilityFemaleHumansMagnetic Resonance ImagingMaleNerve NetSchizophrenic Psychologychildhood traumacognitiondefault modefMRIpsychosisresiliencerestingsalience networkschizophreniatask-negativetemporal variabilitytriple networksworking memory

Identifiers

PMID41943939
PMCPMC13079207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.