Evidence map›Paper›PMID 41943866›Full record

ArticleAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2026

Trends and Future Perspectives in Additive Modifications of Calcium Silicate-Based Cements: A Scoping Review (2015-2024).

Kenta Tsuchiya, Salvatore Sauro, Jukka P Matinlinna, Monica Yamauti, Hidehiko Sano, Kyung-San Min, Atsushi Tomokiyo

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kenta TsuchiyaDepartment of Restorative Dentistry and Endodontics, Hokkaido University, Sapporo, Japan.ORCID https://orcid.org/0009-0006-3920-3448
Salvatore SauroDental Biomaterials and Minimally Invasive Dentistry, Departamento de Odontología, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, Valencia, Spain.
Jukka P MatinlinnaDental Materials Science, Applied Oral Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0001-7656-0678
Monica YamautiDepartment of Restorative Dentistry and Endodontics, Hokkaido University, Sapporo, Japan.ORCID https://orcid.org/0000-0002-0886-4407
Hidehiko SanoDepartment of Restorative Dentistry and Endodontics, Hokkaido University, Sapporo, Japan.
Kyung-San MinDepartment of Conservative Dentistry, School of Dentistry, Jeonbuk National University, Jeonju, Republic of Korea.
Atsushi TomokiyoDepartment of Restorative Dentistry and Endodontics, Hokkaido University, Sapporo, Japan.

Funding

Japan Society for the Promotion of Science KAKENHI JP [25K24051]The Okura Kazuchika Memorial Foundation
6 · The paper itself

Abstract

This scoping review identified commonly modified commercial calcium silicate-based cements (CSCs), evaluate additive-property trends and highlight research gaps relevant to their clinical application. Laboratory studies published between 2015 and 2024 were searched in PubMed, ScienceDirect and Web of Science following PRISMA-ScR. Fifty-one studies met the inclusion criteria, with ProRoot being the most frequently studied CSC. Additive modifications primarily targeted setting time, biocompatibility, antibacterial property and osteogenic differentiation. A recent shift from bioactivity-focused to physicochemical optimization was observed. Heat map analysis demonstrated distinct additive category-property associations, with metals and fluorides mainly linked to antibacterial enhancement, phosphate-based and bioactive compounds to biocompatibility and osteogenic outcomes, and commonly used setting modifiers, including calcium chloride, associated with accelerated setting. These findings indicate that single-category additive strategies are insufficient and that several CSC properties remain underexplored, supporting the need for more integrative CSC design.

Indexed as

Calcium CompoundsDental CementsSilicatesAluminum CompoundsAnti-Bacterial AgentsBiocompatible MaterialsDrug CombinationsHumansOxidesAluminum CompoundsAnti-Bacterial AgentsBiocompatible MaterialsCalcium Compoundscalcium silicateDental CementsDrug Combinationsmineral trioxide aggregateOxidesSilicatesadditivecalcium silicate cementendodonticsmineral trioxide aggregatemodified MTAscoping review

Identifiers

PMID41943866
PMCPMC13436182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.