ArticleMolecular nutrition & food research2026
Therapeutic Modulation of Inflammatory Signaling via Physalis Peruviana-Derived Exosomes: A Targeted Effect on IKK/NFκB/STAT1.
Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Physalis peruviana is a carotenoid-rich fruit widely recognized for its nutritional and medicinal value, yet the molecular mechanisms underlying its bioactivity remain incompletely understood. Plant-derived extracellular vesicles have recently emerged as functional nanocarriers of bioactive metabolites; however, these vesicles from P. peruviana have not been systematically investigated. We isolated and characterized exosomes from P. peruviana fruits and evaluated their anti-inflammatory and antioxidant activities in vitro. Vesicles were isolated and characterized using transmission electron microscopy, nanoparticle tracking analysis, protein and RNA profiling, thin-layer chromatography, and untargeted metabolomics. The vesicles exhibited characteristic exosomal morphology with a mean diameter of ∼142 nm and contained proteins, miRNAs, lipids, and β-carotene as a predominant metabolite. Functional assays revealed that, at non-cytotoxic concentrations (25 µg/mL), they significantly suppressed IL-6, TNF-α, IFN-β, iNOS, and STAT1 expression in LPS-stimulated RAW 264.7 macrophages, accompanied by reduced IKK phosphorylation and inhibition of NF-κB and STAT1 transcriptional activity. In H
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