Evidence map›Paper›PMID 41943853›Full record

ArticleInternational journal of biological sciences2026

Identification of a Novel PDRG1-EZH2-p21 Pathway Controlling Senescence and Tumor Progression in Hepatocellular Carcinoma.

Qiang Yang, Lilong Zhang, Wei Li, Zhengle Zhang, Jing Tao, Yuping Rong, Weixing Wang

Abstract read
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiang YangDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Lilong ZhangDepartment of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People's Republic of China.
Wei LiDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Zhengle ZhangDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Jing TaoDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Yuping RongDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Weixing WangDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) remains a major global health burden with limited therapeutic options and poor prognosis. PDRG1 is upregulated in several malignancies, yet its clinical relevance and mechanistic role in HCC are not fully understood. Here, we investigated the contribution of PDRG1 to HCC progression and delineated the underlying molecular mechanism. Using public datasets, patient specimens,

Indexed as

Carcinoma, HepatocellularCyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinLiver NeoplasmsAnimalsCell Line, TumorCell ProliferationCellular SenescenceGene Expression Regulation, NeoplasticHumansMiceMice, NudeCyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsEnhancer of Zeste Homolog 2 ProteinEZH2 protein, humancellular senescenceEZH2hepatocellular carcinomap21PDRG1

Identifiers

PMID41943853
PMCPMC13050440

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.