Evidence map›Paper›PMID 41943835›Full record

ArticleInternational journal of biological sciences2026

CBX8 suppresses autophagy-dependent senescence in colorectal cancer by modulating the mTOR signaling pathway.

Tiankang Li, Enjian Zhang, Xin Liu, Hui Zhou, Pengbo Zhang, Chong Zhang, Xiuzhong Zhang, Nai Wu, Shuai Gong, Zeqiang Ren and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tiankang LiDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Enjian ZhangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Xin LiuDepartment of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Hui ZhouDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Pengbo ZhangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Chong ZhangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Xiuzhong ZhangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Nai WuDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Shuai GongDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Zeqiang RenDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.
Jie DingDepartment of Gastrointestinal Surgery, Guizhou Provincial People's Hospital; NHC Key Laboratory of Pulmonary Immunological Diseases, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Yi ZhangDepartment of Gastrointestinal Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is among the most common cancers worldwide. Cellular senescence, characterized by an irreversible state of growth arrest, has been recognized as a promising therapeutic strategy for combating cancer. Here, the oncogenic role of Chromobox homolog 8 (CBX8) in CRC and its regulatory mechanisms in cell senescence and transcriptional regulation were systematically investigated. We demonstrated that CBX8 deficiency suppresses colorectal tumorigenesis and promotes tumor cell senescence in both

Indexed as

AutophagyCellular SenescenceColorectal NeoplasmsPolycomb Repressive Complex 1TOR Serine-Threonine KinasesAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceMice, NudeSignal TransductionTranscription FactorsCBX8 protein, humanDDIT4 protein, humanMTOR protein, humanPolycomb Repressive Complex 1TOR Serine-Threonine KinasesTranscription FactorsautophagyCBX8colorectal cancersenescencesenolytic

Identifiers

PMID41943835
PMCPMC13050457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.