ArticleRadiation oncology journal2026
External validation of the graded prognostic assessment for patients with non-small cell lung cancer and brain metastases using molecular markers (Lung-molGPA).
Article in Radiation oncology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposePatients with non-small cell lung cancer (NSCLC) and brain metastases (BM) represent a markedly heterogeneous population. The diagnosis-specific graded prognostic assessment is one of the prognostic indexes, which includes patient age, performance status, extracranial disease, and number of BM. As an updated prognostic model (lung molecular graded prognostic assessment [Lung-molGPA]) with the incorporation of the molecular factor (epidermal growth factor receptor [EGFR] and anaplastic lymphoma kinase [ALK] alterations) was introduced, this study aims to validate the Lung-molGPA model in Korean patient population. MATERIALS AND
methodsFour hundred thirty-three patients (368 adenocarcinoma and 65 nonadenocarcinoma) with NSCLC with newly diagnosed BM between 2005 and 2017 were reviewed retrospectively and scored using the Lung-molGPA model.
resultsThe overall median survival for the cohort in the present study was 14 months (16.5 months in the adenocarcinoma and 8.0 months in the nonadenocarcinoma, respectively; p = 0.003). For patients with adenocarcinoma, the median survival for patients with a Lung-molGPA score of 3.5 to 4.0 was 44.7 months, while the median survival was only 8.9 months in patients scoring 0-1.0, 17.0 months in patients scoring 1.5-2.0, and 30.2 months for scores of 2.5-3.0 (p < 0.001). For patients with nonadenocarcinoma, the median survival for scores 0-1.0, 1.5-2.0, and 2.5-3.0 were 6.7, 10.3, and 13.2 months, respectively (p = 0.041).
conclusionNotable prognostic factors for patients with NSCLC and BM include the patient's age, performance status, metastatic lesions, and the molecular status of the adenocarcinoma. Our independent validation in a single-institution Korean patient cohort confirmed the applicability of Lung-molGPA as a prognostic tool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.