Evidence map›Paper›PMID 41943568›Full record

ArticleRenal failure2026

Physiological glomerular filtration rate and responses to Zeitgeber time and cold stress in C57BL/6 mice.

Xinran Wang, Yanqi Liu, Yu Xin, Hongxu Li, Lifeng Shen, Yu Xiao, Yuchen Song, Linqiong Liu, Kaijiang Yu, Changsong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinran WangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yanqi LiuDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yu XinDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Hongxu LiDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Lifeng ShenDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yu XiaoDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yuchen SongDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Linqiong LiuDepartment of Critical Care Medicine, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Kaijiang YuDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Changsong WangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcutaneous FITC-sinistrin clearance provides a minimally invasive method to measure real-time glomerular filtration rate (GFR) in small animals. However, large-scale physiological reference data and analyses of time-of-day and environmental temperature influences remain limited. We aimed to establish reference values for GFR in healthy C57BL/6 mice and to assess variations related to Zeitgeber timing and cold stress. A total of 200 male mice were studied using a transcutaneous GFR monitoring system under standard conditions, at four Zeitgeber points (ZT2, ZT8, ZT14, ZT18), and following exposure to 4 °C for 2 or 4 h. Baseline GFR was 1.215 ± 0.201 mL/min/100 g body weight. Four-hour cold exposure increased GFR (1.129 ± 0.207 to 1.541 ± 0.333,

Indexed as

Circadian RhythmCold TemperatureGlomerular Filtration RateAnimalsFluorescein-5-isothiocyanateFluoresceinsMaleMiceMice, Inbred C57BLOligosaccharidesReference ValuesTime FactorsFluorescein-5-isothiocyanatefluorescein-isothiocyanate sinistrinFluoresceinsOligosaccharidesC57BL/6 micecold stressGlomerular filtration ratetranscutaneous GFR measurementzeitgeber time

Identifiers

PMID41943568
PMCPMC13059029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.